Cucurbit[8]uril-mediated phosphorescent supramolecular foldamer for antibiotics sensing in water and cells  

作　　者：De-Ao Xu Qing-Yang Zhou Xianyin Dai Xin-Kun Ma Ying-Ming Zhang Xiufang Xu Yu Liu 

机构地区：[1]College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Chinese Chemical Letters》2022年第2期851-854,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (Nos.21871154,21772099,21861132001,and 21873051);the Fundamental Research Funds for the Central Universities,Nankai University。

摘　　要：A phosphorescent supramolecular foldamer is conveniently constructed by the 1:1 host-guest complexation with cucurbit[8]uril and 1,2-diaminocyclohexane-bridged 4-(4-bromophenyl)-pyridinium salt. The tightly compact host-guest complexation in molecular foldamer can greatly suppress the fluorescence emissive channel and promote the intersystem crossing from singlet to triplet states, thus leading to the green phosphorescence at ambient temperature in aqueous solution. More intriguingly, the phosphorescence emission shows very rapid and sensitive responsiveness to different antibiotics in both inanimate milieu and living cells. Remarkably, the limit of detection of such binary inclusion complex toward sulfamethazine can reach as low as 1.86 × 10^(-7) mol/L. Thus, it is envisaged that this supramolecular nanoplatform featuring unique complexation-enhanced phosphorescence emission may hold great promise in sensing and detecting many other biological targets under physiological environment.

关 键 词：Supramolecular assembly CUCURBITURILS Supramolecular foldamer Phosphorescence sensing Antibiotics detection 

分 类 号：O641.3[理学—物理化学]