AND molecular logic gates based on host-guest complexation operational in live cells  

作　　者：Siyang Jiang Weipeng Mao Dake Mao Zhan-Ting Li Da Ma 

机构地区：[1]Department of Chemistry,Fudan University,Shanghai,Shanghai 200433,China [2]College of Chemistry,and Green Catalysis Center,Zhengzhou University,Zhengzhou 450001,China

出　　处：《Chinese Chemical Letters》2022年第2期881-884,共4页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China (Nos.21921003 and 21672042) for financial support。

摘　　要：We report supramolecular AND logic gates based on host-guest complexation between acid-labile acyclic cucurbit[n]uril(CB[n]) molecular container and Na Cl O-responsive dye. Supramolecular AND logic gate is turned on due to acid-triggered degradation of molecular container and the release of the dye, followed by Na Cl O-induced fluorescence “switch on” effect of the dye. The reason for AND molecular logic gate is discovered to be the combination of oxidation inhibition and fluorescence “switch off” effect. Supramolecular AND logic gate is confirmed to be operational in live MCF-7 and He La cancer cells.

关 键 词：Host-guest chemistry Logic gate Stimuli-responsive systems CUCURBITURIL BIOIMAGING 

分 类 号：Q503[生物学—生物化学]