Total syntheses of hyperaspidinols A and B enabled by a bioinspired diastereoselective cascade sequence  

作　　者：Anquan Zheng Tingting Zhou Sasa Wang Wenge Zhang Xiuxiang Lu Huiyu Chen Haibo Tan 

机构地区：[1]Key Laboratory of Plant Resources Conservation and Sustainable Utilization,Key Laboratory of South China Agricultural Plant Molecular Analysis,Guangdong Provincial Key Laboratory of Applied Botany,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,China [2]School of Pharmacy and Bioengineering,Chongqing University of Technology,Chongqing 400054,China [3]Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Guangxi University for Nationalities,Nanning 530006,China [4]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Chemical Letters》2022年第2期885-889,共5页中国化学快报（英文版）

基　　金：supported financially by the National Natural Science Foundation of China (Nos.81773602,21901049 and 21801032);Natural Science Foundation of Guangdong Province (No.2019A1515011694);Guangdong Special Support Program (No.2017TQ04R599);Youth Innovation Promotion Association of CAS (No.2020342);Guangxi Natural Science Foundation (Nos.2018GXNSFBA050015 and AD19245004)。

摘　　要：A bioinspired acid-triggered hemiacetalization/dehydration/[3 + 3]-type cycloaddition cascade process was disclosed, diastereoselectively furnishing furo[2,3-b]chromene skeleton under mild conditions. The viability of this approach was demonstrated by syntheses of a series of furo[2,3-b]chromene and pyrano[2,3-b]chromene derivatives. The successful total syntheses of two lignan-phloroglucinol hybrids,hyperaspidinols A and B, exemplified the synthetic utility of our biomimetic methodology.

关 键 词：Total synthesis Bioinspried DIASTEREOSELECTIVE Cascade reaction Hyperaspidinol 

分 类 号：O626[理学—有机化学]