非水自动电位滴定法测定盐酸精氨酸含量不确定度评定  

Evaluation of Uncertainty in Determination of Arginine Hydrochloride by Nonaqueous Automatic Potentiometric Titration

作　　者：帅玲 黄伟 SHUAI Ling;HUANG Wei(Taizhou Institute for Drug Control,Taizhou 225300,China)

机构地区：[1]泰州市药品检验院,江苏泰州225300

出　　处：《海峡药学》2022年第3期94-96,共3页Strait Pharmaceutical Journal

摘　　要：目的 以盐酸精氨酸为例,建立非水电位滴定法测定药物含量的不确定度评定方法。方法 分析高氯酸标定过程、自动电位滴定过程中的各个因素,并对各个不确定度分量进行评估。结果 当不确定度分布为均匀分布且置信概率为0.95时,扩展不确定度的包含因子k=2,其扩展不确定度U为0.716%。结论 所建立的不确定度评估方法可为非水自动电位滴定法测定药物含量的结果评定提供参考。OBJECTIVE Taking arginine hydrochloride as an example,the uncertainty evaluation method of nonaqueous potentiometric titration was established.METHODS The factors in the process of perchloric acid calibration and automatic potentiometric titration were analyzed,and the uncertainty components were evaluated.RESULTS When the uncertainty distribution was uniform and the confidence probability was 0.95,the coverage factor of expanded uncertainty k=2,and the expanded uncertainty U was 0.664%.CONCLUSION The uncertainty evaluation method can provide a reference for the evaluation of the results of non-aqueous automatic potentiometric titration.

关 键 词：非水滴定 不确定度 盐酸精氨酸 自动电位滴定 

分 类 号：R927[医药卫生—药学]