中老年Kimura病患者临床特点分析  

Clinical characteristics of middle-aged and elderly patients with Kimura disease

作　　者：张雪晗 焦洋 黄晓明 曾学军 ZHANG Xue-Han;JIAO Yang;HUANG Xiao-Ming;ZENG Xue-Jun(Department of Health Care,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of General Practice(General Internal Medicine),Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院保健医疗部,北京100730 [2]中国医学科学院北京协和医院全科医学科(普通内科),北京100730

出　　处：《中华老年多器官疾病杂志》2022年第3期166-169,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：科技部公共安全风险防控与应急技术装备(2020YFC0841300);美国中华医学基金会公开竞标项目(CMB-OC)(20-384)。

摘　　要：目的评估和比较中老年Kimura病患者与青年患者的临床特点,以期提高对此病的认识。方法回顾性分析1980年1月至2020年12月于中国医学科学院北京协和医院经病理确诊的Kimura病患者的临床资料,按照年龄不同分为中老年组(≥45岁)和青年组(18~44岁)。比较2组患者流行病学特点、临床表现、实验室检查、诊治及转归情况。采用SPSS 22.0统计软件进行数据分析。根据数据类型,分别采用t检验、Mann-Whitney U检验或χ^(2)检验进行组间比较。结果本研究共纳入Kimura病患者52例,其中中老年组(≥45岁)20例(38.5%),青年组(18~44岁)32例(61.5%)。中老年组Kimura病患者肿物直径5.0(4.0,6.3)cm,明显高于青年组的3.0(2.0,4.0)cm,差异有统计学意义(P<0.05);出现皮肤瘙痒和皮肤色素沉着的比例分别为70.0%(14/20)和35.0%(7/20),高于青年组[40.6%(13/32)和3.1%(1/32)],差异均有统计学意义(均P<0.05)。2组之间在性别比例、出现症状到确诊时间、并发症、多部位受累、涎腺受累、血嗜酸性粒细胞数量、血清总免疫球蛋白E水平、病理活检部位选取、治疗方式及预后,差异均无统计学意义。结论中老年Kimura病患者并非罕见,其临床特征与青年患者差别不明显。但中老年患者肿物更大,且出现皮肤瘙痒和色素沉着更常见。Objective To evaluate and compare the clinical characteristics of middle-aged and elderly Kimura disease patients with young patients,so as to enhance better understanding of the disease.Methods The clinical data of the patients with pathologically confirmed Kimura disease in Peking Union Medical College Hospital from January 1980 to December 2020 were collected.The patients were divided into middle-aged and elderly group(≥45 years old)and young group(18-44 years old).The epidemiological characte-ristics,clinical manifestations,results of laboratory examinations,diagnosis,treatment and outcomes of these patients were analyzed retrospectively,and the differences between them were compared.SPSS statistics 22.0 was used for data analysis.According to the different data types,student′s t test,Mann-Whitney U test or Chi-square test was adopted for comparison between groups.Results A total of 52 patients with Kimura disease were included in this study,including 20 cases(38.46%)in the middle-aged and elderly group and 32 cases(61.54%)in the young group.The middle-aged and elderly group had significantly larger tumor size[5.0(4.0,6.3)vs 3.0(2.0,4.0)cm]and higher proportions of skin itching[70.0%(14/20)vs 40.6%(13/32)]and skin pigmentation[35.0%(7/20)vs 3.1%(1/32)]than the young group(all P<0.05).There were no statistical differences between the 2 groups in gender ratio,time from symptom onset to diagnosis,complications,multi-site involvement,salivary gland involvement,blood eosinophil count,and IgE level,biopsy sites,treatment options and prognosis.Conclusion The prevalence of Kimura disease is not rare in the middle-aged and elderly people.Their clinical characteristics does not differ from those of young patients.But larger tumor mass,skin itching and pigmentation are more common in the middle-aged and elderly patients.

关 键 词：KIMURA病 临床特征 年龄 中老年 

分 类 号：R5[医药卫生—内科学]