活检联合TCT、HR-HPV检测在宫颈疾病中的应用  被引量:5

Clinical Biopsy,TCT and HR-HPV on Detection of Cervical Diseases

在线阅读下载全文

作  者:陈雁娜 CHEN Yanna(Gynecology Department,Taishan People’s in Guangdong,Taishan Guangdong 529200,China)

机构地区:[1]广东省台山市人民医院妇科,广东台山529200

出  处:《中国卫生标准管理》2022年第6期84-87,共4页China Health Standard Management

摘  要:目的分析子宫颈癌前病变和子宫颈癌采用阴道镜下宫颈活检、液基细胞学检查和高危型人乳头瘤病毒检测效果。方法选择在本院实施子宫颈癌筛查的200例女性为研究样本,其研究时间均在2019年6月—2020年6月。全部女性均实施液基细胞学检查(thinprep cytology test,TCT)以及高危型人乳头瘤病毒检测(high risk human papillomavirus,HR-HPV),对于检测结果提示为阳性的病患再实施阴道镜下宫颈组织活检。比较TCT检查以及HR-HPV检测阳性率、阴性率以及敏感度;分析TCT检查与HR-HPV检测分别联合阴道镜下宫颈活检阳性例数以及分布情况。结果在检测阳性率方面,TCT检查为18.00%,低于HR-HPV检测的30.00%;在敏感度方面,TCT检查为94.44%,高于HR-HPV检测的83.33%(P<0.05)。TCT检查联合阴道镜下宫颈活检提示阳性结果为34例,阳性率17.00%,其中CINⅡ及以上占比61.76%。HR-HPV检测联合阴道镜下宫颈活检提示阳性结果为50例,阳性率25.00%,其中CINⅡ及以上者占比38.00%。TCT检查联合活检诊断CINⅡ及以上者阳性率高于HR-HPV检测联合阴道镜下宫颈活检(P<0.05)。结论TCT检查联合阴道镜下宫颈活检与HR-HPV检测联合阴道镜下宫颈活检均能应用于子宫颈癌前病变和子宫颈癌疾病检查,联合检测可弥补单一检测方式的不足,提升检测准确性。Objective To analyze the effects of colposcopy-guided cervical biopsy,thinprep cytology test(TCT)and high-risk human papillomavirus(HR-HPV)on detection of cervical intraepithelial neoplasia(CIN)and cervical cancer.Methods A total of 200 women of undergoing the cervical cancer screening from June 2019 to June 2020 in our hospital were selected.TCT and HR-HPV were conducted and then the colposcopy-guided cervical biopsy was applied for positive cases.Positive and negative detection rates and diagnosis sensitivity based on TCT and HR-HPV were compared.The positive detection cases and distribution conditions based on TCT,HR-HPV and colposcopy-guided cervical biopsy were analyzed.Results The positive detection rate based on TCT(18.00%)was lower than HRHPV(30.00%);the diagnosis sensitivity based on TCT(94.44%)was higher than HR-HPV(83.33%)(P<0.05).TCT examination combined with colposcopy cervical biopsy suggested positive results in 34 cases,with a positive rate of 17.00%,of which CIN and above accounted for 61.76%.HR-HPV testing combined with colposcopy cervical biopsy suggested positive results of 50 cases,with a positive rate of 25.00%,of which CINⅡand above accounted for 38.00%.TCT and biopsy diagnosis of CIN and above was higher than HR-HPV and colposcopy cervical biopsy(P<0.05).Conclusion Both of TCT with colposcopy-guided cervical biopsy or HR-HPV with colposcopy-guided cervical biopsy has fair effects for detection of cervical intraepithelial neoplasia and cervical cancer.Therefore,the combined examinations can increase the diagnosis accuracy by comparison to single examination.

关 键 词:子宫颈癌 癌前病变 高危型人乳头瘤病毒 液基细胞学检查 宫颈活检 阴道镜 

分 类 号:R446[医药卫生—诊断学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象