GnRHa联合孕三烯酮对子宫内膜异位症患者PRL、sHLA-G及对妊娠结局的影响  

Effects of GnRHa combined with gestrinone on PRL,sHLA-G and pregnancy outcome in patients with endometriosis

作　　者：王凤芹 邢彦彦 高涵 王新忠 WANG Fengqin;XING Yanyan;GAO Han;WANG Xinzhong(Department of Obstetrics and Gynecology,Jinshan Hospital of Fudan University,Shanghai 201508,China)

机构地区：[1]复旦大学附属金山医院妇产科,上海201508

出　　处：《中国优生与遗传杂志》2022年第3期464-468,共5页Chinese Journal of Birth Health & Heredity

基　　金：hCG比值联合超声阅值快速诊断异位妊娠的前瞻性研究(JSKJ-KTMS 2016-02)。

摘　　要：目的 分析促性腺激素释放激素激动剂(GnRHa)联合孕三烯酮对子宫内膜异位症患者泌乳素(PRL)、可溶性人类白细胞抗原-G(sHLA-G)及对妊娠结局的影响。方法 选取在我院2018年1月至2020年10月期间治疗子宫内膜异位症的患者110例,随机分为对照组和观察组,每组各55例。对照组治疗使用孕三烯酮胶囊进行治疗,观察组在服用孕三烯酮胶囊的同时进行GnRHa治疗。对比两组患者治疗前后黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)水平,纤溶酶原激活物抑制因子-1(PAI-1)、可溶性人类白细胞抗原-G(sHLA-G)、巨噬细胞移动抑制因子(MMIF)水平、白细胞介素(IL-1β)、肿瘤坏死因子(TNF-α),妊娠结局,临床疗效等。结果 治疗后两组LH、PRL、E2水平降低,且观察组LH、PRL、E2水平低于对照组,具有统计学差异(P<0.05),治疗后两组PAI-1、sHLA-G、MMIF水平降低,且观察组PAI-1、sHLA-G、MMIF水平低于对照组,具有统计学差异(P<0.05),治疗后两组IL-1β、TNF-α水平降低,且观察组IL-1β、TNF-α水平低于对照组,具有统计学差异(P<0.05),观察组妊娠率较高,不良妊娠结局较少,具有统计学差异(P<0.05),治疗后与对照组相比,观察组总有效率较高,具有统计学差异(P<0.05)。结论 子宫内膜异位症患者经GnRHa联合孕三烯酮治疗后,PRL、sHLA-G水平均显著降低,不良妊娠结局较少,且治疗效果明显。Objective To analyze the effects of gonadotropin releasing hormone agonist(GnRHa) combined with gestrinone on prolactin(PRL),soluble human leukocyte antigen-G(sHLA-G) and pregnancy outcome in patients with endometriosis.Methods A total of 110 patients with endometriosis who were treated in our hospital from January 2018 to October 2020 were selected and randomly divided into a control group and an observation group,with 55 cases in each group.The control group was treated with gestrinone capsules for treatment,while the observation group was treated with GnRHa while taking gestrinone capsules.The levels of luteinizing hormone(LH),prolactin(PRL),estradiol(E2),plasminogen activator inhibitor-1(PAI-1),soluble human leukocyte antigen-G(sHLA-G),macrophage migration inhibitory factor(MMIF) levels,interleukin(IL-1β),tumor necrosis factor(TNF-α),pregnancy outcome,clinical efficacy,etc.Results After treatment,the levels of LH,PRL and E2 in the two groups decreased,and the levels of LH,PRL and E2 in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of PAI-1,sHLA-G and MMIF in the two groups decreased,and the levels of PAI-1,sHLA-G and MMIF in the observation group were lower than those in the control group(P<0.05),IL-1β in the two groups after treatment β,TNF-α The level of IL-1 in the observation group decreased β,TNF-α The level was significantly lower than that in the control group(P<0.05),the pregnancy rate were higher and adverse pregnancy outcomes were less in the observation group,with statistical difference(P<0.05).After treatment,the total effective rate of the observation group was higher than that of the control group(P<0.05).Conclusion After treatment with GnRHa combined with gestrinone,the average PRL and sHLA-G levels in patients with endometriosis were significantly reduced,the adverse pregnancy outcomes were less,and the treatment effect was obvious.

关 键 词：促性腺激素释放激素激动剂 孕三烯酮 子宫内膜异位症 泌乳素 可溶性人类白细胞抗原-G 

分 类 号：R711.71[医药卫生—妇产科学]