利福平致急性肾损伤1例分析  

One case of acute kidney injury induced by rifampicin

作　　者：任全霞 吴彬[2] 黄明霞[1] REN Quanxia;WU Bin;HUANG Mingxia(Department of Pharmacy,the First People’s Hospital of Yinchuan,Yinchuan Ningxia 750001,China;Department of Pharmacy,the First People’s Hospital of Guangzhou,Guangzhou Guangdong 510000,China)

机构地区：[1]银川市第一人民医院药学部,宁夏银川750001 [2]广州市第一人民医院药学部,广东广州510000

出　　处：《中国药物警戒》2022年第4期453-455,共3页Chinese Journal of Pharmacovigilance

基　　金：宁夏回族自治区卫生计生委重点研究课题(2018-NW-066)。

摘　　要：目的探讨利福平致急性肾损伤的处置措施。方法分析1例利福平致急性肾损伤患者诊疗经过,结合文献分析,探索利福平诱发急性肾损伤的机制及处理措施。结果患者第2次口服利福平后复查血肌酐值为477.2μmol·L^(-1),立即停药,先后行10次血液透析治疗后,血肌酐值由579.2μmol·L^(-1)降至80.6μmol·L^(-1)。结论利福平导致急性肾损伤时应立即停药,并根据肾功能损伤程度采取相应的治疗措施。Objective To explore ways in which acute kidney injury induced by rifampicin can be treated.Methods The process of treating one case of rifampicin-induced acute kidney injury was analyzed.The possible pathogenesis and treatments of rifampicin-induced acute kidney injury were discussed based on literature review.Results The serum creatinine was 477.2 mol·L^(-1) after the second oral rifampicin.Rifampicin was immediately withdrawn and hemodialysis was performed ten times.The serum level of creatinine decreased from 579.2 mol·L^(-1) to 80.6 mol·L^(-1).Conclusion Rifampicin should be withdrawn immediately after acute kidney injury,and corresponding treatments should be provided according to the severity of acute kidney injury.

关 键 词：利福平 抗结核病药 急性肾损伤 药品不良反应 

分 类 号：R994.11[医药卫生—毒理学]