有机化学实验综合设计:9,9-二正丙基-2-硝基芴的高效合成  

Comprehensive Design of the Organic Chemistry Experiment:Efficient Synthesis of 9,9-Dipropyl-2-Nitrofluorene

作　　者：孟祥太[1] 王世彬 王旭达[3] 缪宇浩 罗艳 张芮源 梁茂[1] 无 Meng Xiangtai;Wang Shibin;Wang Xuda;Miao Yuhao;Luo Yan;Zhang Ruiyuan;Liang Mao;无(School of Chemical Engineering,Tianjin University of Technology,Tianjin 300384,China;Southwest Petroleum University,Chengdu 610500,China;Tianjin Experimental High School,Tianjin 300202,China)

机构地区：[1]天津理工大学化学化工学院,天津300384 [2]西南石油大学,四川成都610500 [3]天津市实验中学,天津300202

出　　处：《山东化工》2022年第6期201-203,共3页Shandong Chemical Industry

基　　金：天津理工大学教改项目新工科背景下有机化学一流课程建设实践(YB21-10);西南石油大学研究生教研教改项目(18YJYB02);四川省2021-2023年高等教育人才培养质量和教学改革项目(JG2021-582),基于“双一流”高校与企业联合的教师创新创业教育能力提升机制研究。

摘　　要：硝化和亲核取代都是有机化学的经典反应,在本科基础有机化学教学中占有重要地位。然而,由于课时有限,经费不足,部分高校基础有机化学实验开设不足,现有合成制备实验无法满足日益提高的教学要求。发展综合性强,反应时间短,重复性好,且实验成本低的有机合成制备实验是解决上述问题的有效手段。本实验紧密结合当今有机化学发展前沿,设计了以芴为反应原料,以有机半导体材料中间体9,9-二正丙基-2-硝基芴为目标产物的创新实验方案。该实验在8 h内连续完成硝化和亲核取代两步反应,涵盖萃取、重结晶、柱层析等多种重要有机合成技能训练。实验时间短,重复性好,且成本低,符合基础有机化学实验教学在培养拔尖创新人才方面的新要求。Both nitrification and nucleophilic substitution are classical reactions in organic chemistry and play an important role in basic organic chemistry teaching.However,due to the limited class hours and lack of funds,some universities do not have enough basic organic chemistry experiments.The present experiments cannot meet the increasing teaching requirements.An effective method to solve the above problems is to develop an organic synthesis experiment with high comprehensiveness,short reaction time,good repeatability,and low experimental cost.In this experiment,an innovative experiment with fluorene as raw material and organic semiconductor material intermediate 9,9-dipropyl-2-nitrofluorene as the target product was designed.The experiment completed nitrification and nucleophilic substitution in eight hours,covering a variety of important organic synthesis skills training.The experiment has the advantages of short reaction time,good repeatability,and low cost,which meets the new requirements of basic organic chemistry experiment teaching in cultivating top innovative talents.

关 键 词：硝化反应 亲核取代反应 芴 有机半导体材料 

分 类 号：TK730.2[交通运输工程—轮机工程] O357.5[动力工程及工程热物理—流体机械及工程]