强心苷类化合物的老药新用  

New use of old drugs cardiac glycosides

作　　者：任俊玮 郭喜 王欣 王宁 REN Jun-wei;GUO Xi;WANG Xin;WANG Ning(Pharmacology Teaching and Research Section,Pharmacy School,Harbin Medical University,Harbin,Heilongjiang,150081,China)

机构地区：[1]哈尔滨医科大学药学院药理学教研室,黑龙江哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院甲状腺外科 [3]哈尔滨医科大学附属第四医院药学部

出　　处：《心血管康复医学杂志》2022年第2期210-213,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：国家自然科学基金面上项目(81773733,82170284);黑龙江省应用技术研究与开发计划重大项目(GA18C006)。

摘　　要：强心苷是一类广泛分布于自然界的苷类化合物,目前多种强心苷类药物被批准用于临床心力衰竭和心房颤动的治疗。近年研究发现,强心苷具有广泛药理活性,如抗病毒感染和调节免疫炎症反应等。本文对强心苷的临床应用、作用机制及药理活性进展进行综述,并对其潜在临床价值和研究方向进行分析和展望。Cardiac glycosides(CGs)are a class of glycoside compounds widely distributed in nature.Several kinds of cardiac glycosides have been approved for treatment of clinical heart failure and atrial fibrillation.Recent studies have found that cardiac glycosides have more extensive pharmacological activities,such as anti-viral infection and regulation of immune inflammatory response etc.The present article makes a review on clinical application,mechanism,and advances in pharmacological activity of cardiac glycosides and analyzes,prospects its potential clinical value and research direction.

关 键 词：强心甙类 抗病毒药 炎症 

分 类 号：R972.1[医药卫生—药品]