HMGB1和TLR4在ARDS中作用的研究进展  

Research progress on the role of high mobility group protein B1 and Toll-like receptor 4 in ARDS

作　　者：舒小燚 李有霞 范绍辉 王红嫚 SHU Xiaoyi;LI Youxia;FAN Shaohui;WANG Hongman(Department of Respiratory and Critical Care Medicine,the Fifth Affiliated(Zhuhai)Hospital of Zunyi Medical University,Zhuhai 519100,China)

机构地区：[1]遵义医科大学第五附属(珠海)医院呼吸与危重症医学科,519100

出　　处：《天津医药》2022年第4期433-438,共6页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81960023);贵州省卫生健康委科学技术基金项目(gzwkj2021-093)。

摘　　要：急性呼吸窘迫综合征(ARDS)的发病机制复杂,炎症反应在ARDS的病理进程中具有关键作用。高迁移率族蛋白B1(HMGB1)和Toll样受体4(TLR4)是促发炎性反应的关键介质,许多证据表明HMGB1和TLR4在ARDS中发挥重要作用,可能成为ARDS的治疗靶点。就HMGB1、TLR4和HMGB1/TLR4信号通路在ARDS炎症发展中的作用及相关治疗进展进行综述。The pathogenesis of acute respiratory distress syndrome(ARDS)is complex,inflammation plays an important role in the pathological process of ARDS.Many studies have shown that high mobility group box 1 protein(HMGB1)and toll-like receptor 4(TLR4),as inflammatory mediators,are important components in ARDS,which may become the therapeutic target of ARDS.This article reviews the role of HMGB1,TLR4 and HMGB1/TLR4 signaling pathway in the development of inflammation and the related treatment progression of ARDS.

关 键 词：HMGB1蛋白质 TOLL样受体4 呼吸窘迫综合征 成人 急性肺损伤 病原体相关分子模式分子 

分 类 号：R563.9[医药卫生—呼吸系统]