体重异常与肾透明细胞癌临床分期及病理分级的相关性分析  

Correlation between overweight and the grade and stage of clear cell renal carcinoma

作　　者：秦梦杰 马悦 杜娟 QIN Meng-jie;MA Yue;DU Juan(Clinical College of the People′s Liberation Army Affiliated to Anhui Medical University,Hefei 230031,Anhui,China;Department of Military Casualty Management,901st Hospital of the People′s Liberation Army,Hefei 230031,Anhui,China)

机构地区：[1]安徽医科大学解放军临床学院,合肥230031 [2]解放军联勤保障部队第九〇一医院伤病员管理科,合肥230031

出　　处：《医学研究生学报》2022年第4期398-401,共4页Journal of Medical Postgraduates

摘　　要：目的 体重异常能够增加ccRCC发病的风险。文中探讨体重异常与ccRCC临床分期、病理分级的相关性。方法 回顾性分析2014年1月至2020年7月于解放军联勤保障部队第九〇一医院就诊的97例ccRCC患者临床病理资料,以291例健康体检者作对照组,比较2组人群在吸烟、高血压、糖尿病、体质异常(BMI≥25 kg/m^(2))等差异。通过Logistics回归法分析高血压、糖尿病、体质异常与ccRCC的关系。将97例ccRCC患者分为非超重组、超重组和肥胖组,比较三组患者在临床分期及病理分级资料的差异。结果 肾癌组与对照组的高血压、糖尿病、体质异常人数占比差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,超重与ccRCC发病有关(OR=2.283,95%CI:1.359~3.837)。97例ccRCC患者中,非超重组、超重组、肥胖组三组间临床分期差异均具有统计学意义(P<0.05),非超重组和肥胖组的病理分级差异有统计学意义(P<0.05)。结论 高血压、体质异常与ccRCC发病相关,可能会增加ccRCC发病风险。体重异常可能降低ccRCC的分期。肥胖可能降低ccRCC病理分级。Objective Purpose To investigate the correlation between overweight, obesity and the grade and stage of renal clear cell carcinoma. Methods The clinical data of 97 patients undergoing renal clear cell carcinoma surgery and renal pathology were retrospectively analyzed in this study. According to the ratio of age and sex, 291 normal people who underwent physical examination in the physical examination center were used as the control group.The differences in abnormal constitution, smoking, hypertension and DM were compared between the two groups. By using Logistics multi-factor regression analysis, the correlation between abnormal constitution and renal cancer was analyzed, and the renal cancer group was divided into the non-overweight group, overweight group and obesity group, and the differences of relevant pathological data were analyzed. Results Hypertension, DM and overweight prevalence in two groups were compared(P<0.05), and the differences were statistically significant. Logisitic regression analysis suggested that overweight was positively correlated with the risk of renal cancer(OR=2.283,95%CI:1.359~3.837).There were statistical differences among the three groups in the clinical stage(P<0.05),and there were statistically significant differences between the non-overweight group and obesity groups in the Furman nuclear grade(P<0.05). Conclusion Hypertension and abnormal constitution are factors for the risk of clear cell renal cell carcinoma.Overweight and obesity may reduce the stage of clear cell renal cell carcinoma, and obesity may reduce the pathological grade of renal clear cell carcinoma.

关 键 词：超重 肾透明细胞癌 病理特点 相关性 

分 类 号：R692[医药卫生—泌尿科学]