IFN-λ家族基因遗传多态性与HBV感染、病毒复制及清除的关系  

Correlations between genetic polymorphism of IFN-λ family gene and HBV infection,virus replication and clearance

作　　者：郑克溪 张阿梅[1] ZHENG Kexi;ZHANG A-Mei(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,Yunnan,China)

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《生物工程学报》2022年第3期893-902,共10页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(81760364);云南省中青年学术和技术带头人后备人才项目(2019HB002)。

摘　　要：乙型肝炎病毒(hepatitisBvirus,HBV)感染是一个严重的全球性公共卫生问题。HBV感染后会引发肝炎,可进一步发展为肝硬化甚至恶化为肝癌。干扰素λ(interferonλ,IFN-λ)是干扰素家族的成员之一,是抗病毒防御的重要细胞因子。IFN-λ家族包括4个成员,分别为IFN-λ1、IFN-λ2、IFN-λ3和IFN-λ4,已有研究表明该家族基因的遗传多态性与HBV的复制和患者的治疗效果具有相关性。文中从遗传易感的角度总结了IFN-λ家族基因多态性在HBV的感染、患者的病程进展和治疗效果中扮演的角色,从而进一步了解其遗传多态性在HBV感染及其病程中的作用,为HBV感染的预防与患者的治疗提供理论基础,为该类细胞因子作为抗HBV药物的研发提供参考。Hepatitis B virus(HBV)infection is one of the most serious public health problems.HBV infection could lead to hepatitis B,and even further develop into hepatic cirrhosis and hepatocellular carcinoma.Interferon lambda(IFN-λ)is a member of the interferon(IFN)family and an important cytokine for antiviral defense.There are four members in IFN-λfamily,including IFN-λ1,IFN-λ2,IFN-λ3,and IFN-λ4.The genetic polymorphisms in the IFN-λgenes are associated with HBV replication and treatment response of HBV patients.In this review,we summarized the roles of genetic polymorphisms of the IFN-λgenes played in HBV infection,disease progression and treatment,with the aim to better understand their function.This review could serve as a reference for the HBV prevention and treatment of HBV patients,as well as for future clinical usage.

关 键 词：乙型肝炎病毒 干扰素λ 病程进展 治疗效果 

分 类 号：R373.21[医药卫生—病原生物学]