B淋巴细胞活化因子抗体在自身免疫性疾病治疗中的研究进展  

Advances of using antibody against B cell activating factor for treatment of autoimmune diseases

作　　者：林榕榕 陈玉磊 金腾川 曹敏杰[1] LIN Rongrong;CHEN Yulei;JIN Tengchuan;CAO Minjie(College of Ocean Food and Biological Engineering,Jimei University,Xiamen 361021,Fujian,China;Department of Basic Medical Sciences,University of Science and Technology of China,Hefei 230027,Anhui,China)

机构地区：[1]集美大学海洋食品与生物工程学院,福建厦门361021 [2]中国科学技术大学基础医学院,安徽合肥230027

出　　处：《生物工程学报》2022年第3期903-914,共12页Chinese Journal of Biotechnology

基　　金：国家重点研发计划(2018YFD0901004);国家自然科学基金(31772049)。

摘　　要：近几十年来,自身免疫性疾病的治疗已从使用激素和常规免疫抑制药物转向使用生物制剂。B淋巴细胞的增殖及成熟对自身免疫性疾病的发病起到至关重要的作用。其中,肿瘤坏死因子超家族B淋巴细胞活化因子(B cell activating factor,BAFF)及其受体通过调控信号通路介导B淋巴细胞存活,因此BAFF及其受体是自身免疫性疾病的重要治疗靶点。文中阐述了BAFF及其受体在人体免疫系统中的作用机制,同时介绍了BAFF通路的过度活化如何促进系统性红斑狼疮、干燥综合征和类风湿关节炎等自身免疫疾病发展的最新观点。针对以上3种疾病,文中以3种主要的靶向BAFF抗体药物Belimumab、Tabalumab和Atacicept为例,介绍和讨论了其最新的临床试验及临床应用现状。最后提出靶向BAFF通路开发新型治疗自身免疫性疾病的方案和策略。In recent decades,the treatment of autoimmune diseases has moved from the use of hormones and conventional immunosuppressive drugs to biological agents.B cell proliferation and maturation play crucial roles in the development of autoimmune diseases.The tumor necrosis factor superfamily ligand B cell activating factor(BAFF)and its receptor mediate B cell survival through regulating signaling pathways.Therefore,BAFF and its receptors are important therapeutic targets for the treatment of autoimmune diseases.This review describes the mechanism of BAFF and its receptor in the human body system and introduces the latest views on how over-activation of BAFF pathway promotes the development of autoimmune diseases including systemic lupus erythematosus,Sjogren’s syndrome,and rheumatoid arthritis.In connection to the treatment of the above three diseases,this review discusses the clinical trials and application status of three BAFF-targeting antibody drugs,including Belimumab,Tabalumab and Atacicept.Finally,this review proposes new strategies that targeting the BAFF pathway to provide a new treatment for autoimmune diseases.

关 键 词：B淋巴细胞活化因子 B淋巴细胞因子受体 B细胞成熟抗原 跨膜激活剂 钙调节剂 亲环素配体相互作用体 自身免疫疾病 

分 类 号：R593.2[医药卫生—内科学]