具核梭杆菌影响动脉粥样硬化的分子机制  

Research on Molecular Mechanism of Effect of Fusobacterium Nucleatum on Atherosclerosis

作　　者：蒋端 申道南 JIANG Duan;SHEN Daonan(State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周科,四川成都610041

出　　处：《口腔医学研究》2022年第4期308-311,共4页Journal of Oral Science Research

基　　金：国家自然科学基金(编号:81771077)。

摘　　要：动脉粥样硬化是冠状动脉粥样硬化性心脏病、脑卒中等心血管疾病重要的发病和死亡原因。现已证实牙周病与动脉粥样硬化是独立相关的。具核梭杆菌是牙周炎龈下菌斑中常见致病菌,在牙周组织处于炎症状态时,具核梭杆菌可通过受损的毛细血管进入血液循环,而后粘附侵入内皮细胞,破坏内皮完整性,导致内皮功能障碍。同时,具核梭杆菌及其热休克蛋白可导致脂质代谢紊乱,并激活促炎因子,增强炎症反应,最终导致动脉粥样斑块的形成。本文就具核梭杆菌对动脉粥样硬化影响的可能机制进行探讨。Atherosclerosis is an important morbidity and mortality cause of cardiovascular diseases such as coronary heart disease and stroke.It has been confirmed that periodontal disease is independently related to atherosclerosis.Fusobacterium nucleatum is a common pathogenic bacterium in the subgingival plaque of periodontitis.When periodontal tissue is in a state of inflammation,Fusobacterium nucleatum can enter the blood circulation through damaged capillaries,and then adhere to endothelial cells,destroying endothelial integrity and causing endothelial dysfunction.At the same time,Fusobacterium nucleatum and its heat shock protein can activate pro-inflammatory factors,enhance inflammatory response,lead to disorder of lipid metabolism,and eventually lead to the formation of atherosclerotic plaque.Therefore,this article reviews the possible molecular mechanisms of the interaction between Fusobacterium nucleatum and atherosclerosis.

关 键 词：动脉粥样硬化 具核梭杆菌 FadA GROEL 炎症反应 脂质代谢 

分 类 号：R54[医药卫生—心血管疾病]