桑菊饮联合沙丁胺醇改善儿童咳嗽变异型哮喘  

Sangju Soup combined with salbutamol to improve cough variant asthma in children

作　　者：王倩芸 何敏华 胡璐 WANG Qianyun;HE Minhua;HU Lu(Department of Pediatrics,Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang TCM University,Jinhua 321000,China)

机构地区：[1]浙江中医药大学附属金华中医院儿科,浙江金华321000

出　　处：《中国现代医生》2022年第6期20-23,共4页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2021ZB316)。

摘　　要：目的探讨桑菊饮联合沙丁胺醇对咳嗽变异型哮喘患儿的疗效及对白三烯C4(LTC4)、白三烯D4(LTD4)、免疫球蛋白(IgE)、白介素1β(IL-1β)、血清干扰素-γ(IFN-γ)及嗜酸粒细胞计数(EOS)的影响。方法选择2018年3月至2019年3月浙江中医药大学附属金华中医院儿科接诊的65例咳嗽变异型哮喘患儿为研究对象,随机分为观察组35例与对照组30例,两组患儿在常规治疗基础上,对照组给予沙丁胺醇治疗,观察组给予桑菊饮联合沙丁胺醇治疗,治疗8周。对比两组患儿治疗前后临床疗效、肺功能改善情况及血清中LTC4、LTD4、IgE、IL-1β、IFN-γ和EOS含量及不良反应。结果经治疗,观察组临床疗效总有效率显著高于对照组,差异有统计学意义(P<0.05);观察组肺功能指标FEV_(1)/L及FEV_(1)/FVC明显高于对照组,PEF明显低于对照组,差异有统计学意义(P<0.05);观察组血清IFN-γ显著高于对照组,差异有统计学意义(P<0.05),LTC4,LTD4,IgE,IL-1β及EOS显著低于对照组,差异有统计学意义(P<0.05);两组治疗期间不良反应比较,差异无统计学意义(P>0.05)。结论在咳嗽变异型哮喘患儿中使用桑菊饮联合沙丁胺醇治疗效果良好,安全性好,作用机制与调节患儿血清炎症相关因子水平相关。Objective To explove the effect of Sangju soup combined with salbutamol on the LTC4,LTD4,IgE,IL-1β,IFN-γand eosinophil count(EOS)in children with cough variant asthma(CVA).Methods Sixty-five children with cough variant asthma(CVA)who were treated in Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang TCM University from March 2013 to March 2019 were selected as the research objects,and randomly divided into the observation group(n=35)and the control group(n=30).On the basis of conventional treatment,the control group was treated with salbutamol for 8 weeks,and the observation group was treated with Sangju soup combined with salbutamol for 8 weeks.Clinical efficacy,improvement of lung function,serum levels of LTC4,LTD4,IgE,IL-1β,IFN-γand EOS and adverse reactions were compared between the two groups before and after treatment.Results After treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Lung function indexes FEV_(1) and FEV_(1)/FVC in the observation group were significantly higher than those in the control group,while PEF was significantly lower than those in the control group,with statistically significant differences(P<0.05).Serum IFN-γin the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05),while LTC4,LTD4,IgE,IL-1βand EOS in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).No significant difference was observed in adverse reactions between the 2 groups during treatment(P>0.05).Conclusion Sangju Soup combined with salbutamol has good efficacy and safety in the treatment of children with cough variant asthma.The mechanism of action is related to regulating the levels of serum inflammatory factors in children.

关 键 词：咳嗽变异型哮喘 桑菊饮 沙丁胺醇 炎症反应 

分 类 号：R653.1[医药卫生—外科学]