血尿酸和空腹血糖与大动脉弹性的相关研究  

Correlation of serum uric acid and fasting blood glucose with elasticity of large artery

作　　者：任明容 张勇[1] 谭琴[1] 谭静宇[1] 苏静[1] 李永霞 袁丽 REN Mingrong;ZHANG Yong;TAN Qin;TAN Jingyu;SU Jing;LI Yongxia;YUAN Li(Department of Endocrinology,Mianzhu People′s Hospital of Sichuan Province,Mianzhu,Sichuan,618200)

机构地区：[1]四川省绵竹市人民医院内分泌科,四川绵竹618200

出　　处：《实用临床医药杂志》2022年第5期54-57,61,共5页Journal of Clinical Medicine in Practice

基　　金：四川省绵竹市人民医院科研项目资助(2019-KF-005)。

摘　　要：目的 探讨血尿酸和空腹血糖(FBG)与大动脉弹性的相关性。方法 选取健康体检的100例志愿者为研究对象,将其分为血尿酸正常组30例与异常组70例,再根据FBG水平分为正常组30例、调节受损组40例和糖尿病组30例。检测患者肱-踝脉搏波传导速度(ba PWV)和肱踝指数(ABI)值,采用多因素Logistic回归分析高尿酸血症的危险因素,Pearson检验分析血尿酸、FBG与大动脉弹性的相关性。结果 血尿酸异常组高血压和糖尿病患者占比增大,ABI值、甘油三酯(TG)、低密度脂蛋白(LDL-C)、FBG和baPWV均升高,但体质量指数(BMI)降低,差异有统计学意义(P<0.05)。Logistics回归分析显示,BMI、高血压、TG、FBG、baPWV和ABI是高尿酸血症的独立危险因素(P<0.05)。调节受损组和糖尿病组患者腰臀比、脉率、总胆固醇(TC)、LDL-C、FBG以及餐后2 h血糖水平均上升,差异有统计学意义(P<0.05)。Pearson检验显示,血尿酸与FBG呈正相关,与baPWV和ABI呈负相关(P<0.05)。结论 血尿酸和FBG与大动脉弹性具有密切关系,血尿酸与FBG呈正相关,与大动脉弹性呈负相关。Objective To explore the correlation of serum uric acid and fasting blood glucose(FBG) with the elasticity of large artery. Methods A total of 100 healthy people who underwent physical examinations were selected as study subjects, and were divided into normal uric acid group(n=30) and abnormal group(n=70), and they were divided into normal group(n=30), impaired regulation group(n=40) and diabetic group(n=30) according to the level of FBG. The brachial-ankle pulse wave velocity(ba PWV) and brachial-ankle index(ABI) value were detected. Multivariate Logistic regression analysis was used to screen the factors affecting hyperuricemia, and Pearson test was used to analyze the relationship of serum uric acid and FBG with the elasticity of large artery. Results The proportions of patients with hypertension and diabetes, ABI, triglyceride(TG), low density lipoprotein(LDL-C), FBG and baPWV levels in the abnormal group were significantly increased than the normal group, but body mass index(BMI) decreased(P<0.05). Logistics regression analysis showed that BMI, hypertension, TG, FBG, baPWV and ABI were the independent risk factors of hyperuricemia(P<0.05). The waist-to-hip ratio, pulse rate, total cholesterol(TC), LDL-C, FBG and 2 h postprandial blood glucose level in impaired regulation group and diabetic group were significantly increased(P<0.05). Pearson test showed that serum uric acid was positively correlated with FBG, and negatively correlated with baPWV and ABI(P<0.05). Conclusion There are close relationships of serum uric acid and FBG with elasticity of the aorta, serum uric acid is positively correlated with FBG and negatively correlated with elasticity of the large artery.

关 键 词：血尿酸 空腹血糖 大动脉弹性 LOGISTIC回归分析 Pearson检验 

分 类 号：R322.1[医药卫生—人体解剖和组织胚胎学] R58[医药卫生—基础医学]