脂肪因子与2型糖尿病血管病变的研究进展  

Research progress of adipokine and type 2 diabetic angiopathy

作　　者：周洁 张玉冬[2] 刘明[2] Zhou Jie;Zhang Yudong;Liu Ming(Shandong University of Traditional Chinese Medicine,First School of Clinical Medicine,Ji'nan 250355,Shandong,China;Department of Peripheral Vascular Disease,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji'nan 250014,Shandong,China)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250355 [2]山东中医药大学附属医院周围血管病科,山东济南250014

出　　处：《血管与腔内血管外科杂志》2022年第2期192-196,共5页Journal of Vascular and Endovascular Surgery

基　　金：山东省中医药科技发展项目(2019-0204)。

摘　　要：在糖尿病诸多死亡原因中,血管并发症位居首位。脂肪因子对糖尿病前期、糖尿病以及糖尿病并发症的发生发展有着不可忽视的影响,许多脂肪因子更是直接参与到糖尿病血管病变进程中,其机制复杂,尚存在诸多争议,需进一步深入研究,未来有望以其为靶点,研制出防治糖尿病及其并发症的靶向药物,为防治糖尿病及其并发症开辟新的领域。本文主要对一些常见脂肪因子与糖尿病血管病变的关联进行综述,旨在为在临床展开对糖尿病并发症的预防及开创新的理论研讨作贡献。Vascular complications is the leading cause of death for diabetes patients. Adipokine greatly influences the prediabetes, diabetes, and diabetic complications, and many adipokines are directly involved in the process of diabetic vascular lesions, the mechanism of which is complex and there are many controversies, which need to be further studied. In the future, it is expected to develop targeted drugs for the prevention and treatment of diabetes and its complications and opening up a new field for the prevention and treatment of diabetes and its complications by using adipokine as the target. This article mainly introduces the association of some common adipokines with diabetic angiopathy to make contribution to the prevention and development of diabetic complications and innovation of new theoretical research.

关 键 词：脂肪因子 2型糖尿病 糖尿病血管病变 动脉粥样硬化 

分 类 号：R543[医药卫生—心血管疾病]