酰胺质子转移成像技术在遗忘型轻度认知障碍患者中的应用  

Application of amide proton transfer imaging in amnestic mild cognitive impairment

作　　者：韩慧婷 祖涵瑜 陈梦莎 黄娅楠 曹赫 姜兴岳[1] HAN Huiting;ZU Hanyu;CHEN Mengsha;HUANG Yanan;CAO He;JIANG Xingyue(Department of Radiology,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院放射科,山东滨州256603

出　　处：《分子影像学杂志》2022年第2期199-203,共5页Journal of Molecular Imaging

基　　金：山东省自然科学基金(ZR2018LH015)。

摘　　要：目的 探讨采用磁共振酰胺质子转移成像技术(APT)研究遗忘型轻度认知障碍(aMCI)患者各感兴趣脑区的病理生理学变化及其与部分临床认知评分量表相关性的可行性。方法 选取2021年1月~2022年1月神经内科确诊的21例遗忘型轻度认知障碍患者作为病例组,另外选择同期本院体检中心21例健康人员作为对照组,对两组分别进行临床资料分析、临床心理学量表评估,对各感兴趣脑区进行常规磁共振成像及酰胺质子转移成像。结果 与对照组相比,病例组右侧海马、双侧杏仁核区域APT值升高(P<0.05),左侧海马区APT值升高(P<0.01);病例组蒙特利尔认知评估量表、简易精神状态评价量表评分低于对照组(P<0.05);简易精神状态评价量表评分与右侧海马、左侧杏仁核的APT值呈负相关(P<0.05);在蒙特利尔认知评估量表评分的各个子项目评分与各脑区域APT值比较中,aMCI组右侧海马的APT值与视空间及执行功能得分呈负相关(P<0.05),左侧杏仁核及双侧海马区域APT值与记忆力分值呈负相关(P<0.05)。结论 aMCI患者部分脑组织存在一系列病理生理的改变,APT技术作为新兴的功能磁共振成像技术,能够在一定程度上帮助临床医生对aMCI患者进行早期诊断。Objective To investigate the feasibility of using magnetic resonance amide proton transfer imaging(APT) to study the pathophysiological changes in various brain regions of interest in patients with amnestic mild cognitive impairment(aMCI) and its correlation with some clinical cognitive score scales. Methods Twenty-one patients with aMCI diagnosed in the Department of Neurology from January 2021 to January 2022 were selected as the case group, and another twenty-one healthy subjects in the physical examination center of our hospital during the same period were selected as the control group. The clinical data of the two groups were analyzed, the clinical psychological scale was assessed, and routine magnetic resonance imaging and amide proton transfer imaging were performed in each brain region of interest. Results Compared with the control group, APT values in the right hippocampus and bilateral amygdala were significantly increased(P<0.05), and left hippocampus had statistical significance(P<0.01). The clinical scores of MoCA and MMSE in case group were significantly lower than those in control group(P<0.05). MMSE score scale was negatively correlated with APT values of right hippocampus and left amygdala(P<0.05). In the comparison of the APT values in each subitem score of the Montreal Cognitive Assessment score and each brain region, the APT values in the right hippocampus were negatively correlated with visual spatial and executive function scores in the aMCI group(P<0.05), and the APT value of left amygdala and bilateral hippocampus were negatively correlated with memory scores(P<0.05). Conclusion Forgetting in patients with aMCI part of the brain is a series of pathophysiological changes. APT technique, as an emerging functional magnetic resonance imaging technique, can help clinicians to make an early diagnosis of patients with aMCI to a certain extent.

关 键 词：遗忘型轻度认知障碍 酰胺质子转移成像 磁共振成像 影像学诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]