前列腺癌靶向超声造影剂的研究进展  

Advances in targeted ultrasound contrast agents for prostate cancer

作　　者：王慧杰 红华 梁丹艳 WANG Huijie;HONG Hua;LIANG Danyan(Inner Mongolia Clinical College,Inner Mongolia Medical University,Hohhot 010110,China;Department of Ultrasound Medicine,People's Hospital of Inner Mongolia Autonomous Region,Hohhot 010017,China)

机构地区：[1]内蒙古医科大学内蒙古临床医学院,内蒙古呼和浩特010110 [2]内蒙古自治区人民医院超声医学科,内蒙古呼和浩特010017

出　　处：《分子影像学杂志》2022年第2期303-307,共5页Journal of Molecular Imaging

基　　金：内蒙古自治区关键技术攻关计划项目(2019GG101)。

摘　　要：前列腺癌是泌尿系统常见的恶性肿瘤之一,在我国前列腺癌的发病率逐年升高。前列腺癌早期没有明显的临床表现,病情隐匿,容易恶化及移转,当患者出现症状就诊时往往已是中晚期甚至出现了远处转移,错过了最佳的治疗时机,前列腺癌的预后与是否及时诊断密切相关。超声分子成像是通过将目标分子靶向标记物连接到以微气泡为载体的声学造影剂表面制备成的靶向声学造影剂,可显著提高疾病诊断和治疗效果,且对正常组织器官毒副作用较小。超声造影剂所具备的特殊结构和性质,使其可经过一系列的化学修饰,将治疗基因和化疗药物递送至肿瘤区域,提高基因转染效率和药物疗效。本文就前列腺癌靶向超声造影剂在前列腺癌的诊断与治疗方面,阐述几种常用的靶向配体、及其对病灶的治疗方式、多模态成像与治疗的最新进展情况。Prostate cancer is one of the common malignant tumors of the urinary system, and its incidence is increasing year by year in China. The early stage of prostate cancer has no obvious clinical manifestations, and the disease is insidious and prone to deteriorate and metastasize. When patients show symptoms and seek treatment, it is often in the middle and late stage or even distant metastasis, missing the best opportunity for treatment. The prognosis of prostate cancer is closely related to whether it is diagnosed in time. Ultrasound molecular imaging is a targeted acoustic contrast agent prepared by attaching targeted molecular markers to the surface of an acoustic contrast agent with microbubbles carrier, which can significantly improve the diagnosis and therapeutic effects of disease with fewer toxic side effects on normal tissues and organs. The special structure and properties of ultrasound contrast agents allow them to undergo a series of chemical modifications to deliver therapeutic genes and chemotherapeutic drugs to the tumor region, improving the efficiency of gene transfection and drug efficacy. This article describes several commonly used targeting ligands, therapeutic modalities for lesions, and recent advances in multimodality imaging and treatment of prostate cancer with targeted ultrasound contrast agents in the diagnosis and treatment of prostate cancer.

关 键 词：前列腺癌 超声造影剂 靶向成像 靶向治疗 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]