小儿肾母细胞瘤化学治疗合并肝窦阻塞综合征4例临床分析  

Clinical analysis of 4 children with Sinusoidal Obstruction Syndrome during Wilms′tumor chemotherapy

作　　者：孟德光 王佳荣 常晓峰 史奎 滕怀炟 王焕民[2] MENG Deguang;WANG Jiarong;CHANG Xiaofeng;SHI Kui;TENG Huaida;WANG Huanmin(Hebei Baoding Children′s Hospital,Baoding 071000,China;Beijing Children′s Hospital Affiliated to Capital Medical University,Beijing 100045,China)

机构地区：[1]河北保定儿童医院,保定071000 [2]首都医科大学附属北京儿童医院,北京100045

出　　处：《中国小儿血液与肿瘤杂志》2022年第1期49-52,共4页Journal of China Pediatric Blood and Cancer

摘　　要：目的总结小儿肾母细胞瘤化学治疗期间合并肝窦阻塞综合征(SOS)的临床特点,以提高对该病的认识。方法对于2017年8月—2020年8月,在我院行化学治疗的4例肾母细胞瘤患儿合并SOS的临床表现、实验室检查、腹部超声检查、治疗及预后等情况进行回顾性分析。结果4例患儿均出现腹胀、肝脏肿大、肝脏弹性值增大、脾脏大、腹水、肝功能异常、凝血功能异常等相同的临床症状,及时给予对症治疗,均预后良好。结论放线菌素D可引起严重肝损害,如出现腹胀伴有肝大、腹水、凝血功能异常等表现,需警惕SOS的发生,及时干预性治疗可改善预后。Objective To summarize the clinical features of sinusoidal obstruction syndrome(SOS)in children during Wilms′tumor chemotherapy so as to improve the understanding of this disease.Methods Data including clinical manifestations,laboratory examination,abdominal ultrasonography,treatment and prognosis etc.of 4 cases of SOS children undergoing chemotherapy in Hebei Baoding children′s Hospital from August 2017 to August 2020 were analyzed retrospectively.Results All the 4 children had the same clinical symptoms including abdominal distension,hepatomegaly,increased liver elasticity,splenomegaly,ascites,abnormal liver function and coagulation function.Timely symptomatic treatment showed good prognosis.Conclusions During chemotherapy with actinomycin D in children with nephroblastoma,while symptoms including abdominal distension accompanied by large liver,ascites,abnormal coagulation function and so on occurred,we should pay attention to SOS early and timely,prompt intervention therapy has great effect on improving the prognosis.

关 键 词：肝窦阻塞综合征 Wilms瘤治疗 肾母细胞瘤化疗 放线菌素D 

分 类 号：R725.7[医药卫生—儿科] R737.11[医药卫生—临床医学]