威伐光治疗外伤引起的难治性皮肤溃疡疗效观察  

Observation on curative effect of WIRA on patients with traumatic refractory skin ulcer

作　　者：宋业专 唐中书 SONG Ye-zhuan;TANG Zhong-shu(Dermatology Hospital of Guangxi Zhuang Autonomous Region,Nanning 530003,Guangxi,China)

机构地区：[1]广西壮族自治区皮肤病医院,广西南宁530003

出　　处：《生物医学工程与临床》2022年第2期169-173,共5页Biomedical Engineering and Clinical Medicine

基　　金：广西皮肤性病科临床重点专科建设项目基金资助项目﹝桂卫医发[2019]44号﹞;广西卫生健康委员会自筹经费科研课题(Z20180361)。

摘　　要：目的观察威伐光治疗外伤引起的难治性皮肤溃疡患者疗效。方法选择2018年6月至2020年6月于广西壮族自治区皮肤病医院收治外伤引起的难治性皮肤溃疡患者60例。随机分为对照组和观察组,每组30例。对照组男性17例,女性13例;年龄31~69岁,平均年龄52.87岁;病程9~47个月,平均病程18.86个月;锐器引起的损伤性皮肤溃疡19例,跌伤引起的皮肤溃疡11例。观察组男性15例,女性15例;年龄32~70岁,平均年龄53.05岁;病程10~48个月,平均病程19.01个月;锐器引起的损伤性皮肤溃疡17例,跌伤引起的皮肤溃疡13例。对照组手术清创后包敷湿润烧伤膏;观察组手术清创后给予威伐光深部热治疗。观察两组治疗前和治疗2、4、6、12周疮面积分、皮肤病生存质量(DLQI))评分、情绪评价。结果疮面积分组内比较:对照组治疗12周与治疗2周差异无统计学意义(163分vs 255分。t=5.853,P>0.05);观察组治疗12周与治疗2周差异有统计学意义(76分vs 245分。t=1.927,P<0.05)。疮面积分组间比较:两组治疗2周比较,差异无统计学意义(t=6.482,P>0.05);治疗4、6、12周,观察组明显低于对照组(138分vs213分、104分vs 201分、76分vs 163分),差异有统计学意义(t=3.022、2.117、1.249,P<0.05)。DLQI评分组内比较:对照组治疗12周与治疗2周差异无统计学意义[(10.64±1.99)分vs(16.74±4.46)分](t=13.972,P>0.05);观察组治疗12周与治疗2周差异有统计学意义[(7.23±0.21)分vs(11.11±2.07)分](t=1.738,P<0.05)。DLQI评分组间比较:治疗2、4、6、12周,观察组低于对照组[(13.24±2.54)分vs(16.74±4.46)分、(11.11±2.07)分vs(14.07±3.61)分、(9.96±1.87)分vs(12.63±2.89)分、(7.23±0.21)分vs(10.64±1.99)分],差异有统计学意义(t=8.794、6.261、4.353、2.117,P<0.05)。情绪评价(心理、社交、性行为三维度)组内比较:对照组治疗12周与治疗2周差异无统计学意义(139分vs 234分。t=26.754,P>0.05);观察组治疗12周与治疗2周差异有统�Objective To observe the curative effect of WIRA in the treatment of patients with refractory skin ulcers caused by trauma.Methods From June 2018 to June 2020,a total of 60 patients with refractory skin ulcers caused by trauma were enrolled,they were randomly divided into control group(n=30)and observation group(n=30).Control group included 17 males and 13 females,aged 31-69 years old with mean age of 52.87 years old;course of disease was 9-47 months with mean of18.86 months;19 cases of traumatic skin ulcers caused by sharps and 11 of skin ulcers caused by falls.Observation group included 15 males and 15 females,aged 32-70 years old with mean age of 53.05 years old;course of disease was 10-48 months with mean of 19.01 months;17 cases of traumatic skin ulcers caused by sharps and 13 of skin ulcers caused by falls.The control group was treated with moist burn ointment after surgical debridement,and observation group performed Wevaguang deep hyperthermia after surgical debridement.The sore area,dermatological quality of life(DLQI)score,and emotional evaluation before treatment and at 2,4,6,and 12 weeks after treatment were observed.Results The area of sores comparison within groups:there was no significant difference between 12-week and 2-week post treatment(163 scores vs 255 scores.t=5.853,P>0.05)in control group,while statistical difference between 12 weeks and 2 weeks after treatment(76 scores vs 245 scores.t=1.927,P<0.05)was found in observation group.The area of sores comparison between 2 groups:there was no significant difference in sore area after 2-week treatment between 2 groups(t=6.482,P>0.05),while 4-,6-,and 12-week after treatment,the observation group were statistically significantly lower than those of control group(138 scores vs 213 scores,104 scores vs 201 scores,76 scores vs 163 scores.t=3.022,2.117,1.249,P<0.05).The DLQI score comparison within groups:in control group,there was no significant difference between 12-week and 2-week after treatment[(10.64±1.99)scores vs(16.74±4.46)scores](t=13.972,P

关 键 词：威伐光 外伤 难治性皮肤溃疡 治疗效果 情绪 

分 类 号：R632.1[医药卫生—外科学] R751.05[医药卫生—临床医学]