国产一次性经口胆道镜的动物实验研究  

Evaluation of a China-made disposable peroral cholangioscope in an animal experiment

作　　者：董礼 王帆[1] 朱跃 杨鹏程 李相林[1] 聂海行 方军[1] 王红玲[1] 赵秋[1] Dong Li;Wang Fan;Zhu Yue;Yang Pengcheng;Li Xianglin;Nie Haihang;Fang Jun;Wang Hongling;Zhao Qiu(Department of Gastroenterology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院消化内科,武汉430071

出　　处：《中华消化内镜杂志》2022年第3期220-224,共5页Chinese Journal of Digestive Endoscopy

基　　金：湖北省科技创新专项重大项目(2017ACA169);武汉大学中南医院优秀博士(博士后)项目(ZNYB2019003)。

摘　　要：目的评估国产一次性经口胆道镜在动物胆道镜检查中的有效性和安全性。方法6头健康巴马小型猪分别于麻醉后行国产一次性经口胆道镜检查,评价其操作性能、图像质量并记录术中和术后并发症。结果6例动物均完成国产一次性经口胆道镜检查。该胆道镜操作性能良好,能顺利通过十二指肠镜进入胆道,注水、吸引及器械通道通畅。胆道镜图像清晰、颜色分辨率良好,未出现图像变形及失真,可准确评估管腔内情况及清晰观察黏膜表面情况。检查过程中未产生出血、穿孔等操作性损伤,以及呼吸抑制、心脏骤停等不良事件。术后所有猪存活状态良好,无不良反应。结论国产一次性经口胆道镜操作性能良好,图像质量高,安全性较好。Objective To evaluate the efficacy and safety of a China-made disposable peroral cholangioscope in animal cholangioscopy.Methods Six healthy Bama minipigs underwent the domestic disposable peroral cholangioscopy after anesthesia.The operation performance and image quality of the products were evaluated,and intraoperative and postoperative complications were recorded.Results All 6 animals received the domestic disposable peroral cholangioscopy.The cholangioscope showed good operating performance and could smoothly enter the biliary tract through the duodenoscope.The water injection,suction and instrument channels were unobstructed.The cholangioscopic image was clear,the color resolution was good,and there was no image distortion.The lumen and the mucosal surface could be accurately assessed.During the examination,there was no operative injuries such as bleeding,perforation,or adverse events such as respiratory depression or cardiac arrest.All pigs survived the operation with no adverse reaction.Conclusion The China-made disposable peroral cholangioscope is safe,with good operability and high-quality image.

关 键 词：动物实验 经口胆道镜 国产 

分 类 号：R657.4[医药卫生—外科学]