Sinkihwan-gamibang ameliorates puromycin amino nucleoside-induced nephrotic syndrome  

作　　者：Lee Hyeon Kyoung Jang Youn Jae Na Se Won Kim Hye Yoom Han Bywig Hyuk Lee Yun Jung Lee Ho Sub Yoon Jung Joo Kang Dae Gill 

机构地区：[1]Hanbang Cardio-Renal Syndrome Research Center,Wonkwang University,Jeollabukdo 54538,Republic of Korea [2]College of Oriental Medicine and Professional Graduate School of Oriental Medicine,Wonkwang University,Jeollabukdo 54538,Republic of Korea

出　　处：《Chinese Journal of Natural Medicines》2022年第3期177-184,共8页中国天然药物（英文版）

基　　金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIP)(Nos.2017R1A5A2015805,2021R1A2C1010859,and 2021R1C1C2009542).

摘　　要：Nephrotic syndrome(NS)is a kidney disease characterized by hypertriglyceridemia,massive proteinuria,hypo-albuminemia and peripheral edema.Sinkihwan-gamibang(SKHGMB)was recorded in a traditional Chinese medical book named“Bangyakhappyeon(方藥合編)”and its three prescriptions Sinkihwan,Geumgwe-sinkihwan,and Jesaeng-sinkihwan belong to Gamibang.This study confirmed the effect of SKHGMB on renal dysfunction in an NS model induced by puromycin aminonucleoside(PAN).The experimental NS model was induced in male Sprague Dawley(SD)rats through injection of PAN(50 mg·kg^(-1))via the femoral vein.SKHGMB not only reduced the size of the kidneys increased due to PAN-induced NS,but also decreased proteinuria and ascites.In addition,SKHGMB significantly ameliorated creatinine clearance,creatinine,and blood urea nitrogen.SKHGMB relieved glomeruli dilation and tubules fibrosis in the glomeruli of the NS model.SKHGMB inhibited the protein and mRNA levels of the NLRP3 inflammasome including NLRP3,ASC,and pro-caspase-1 in NS rats.SKHGMB reduced the protein and mRNA levels of fibrosis regulators in NS rats.The results indicated that SKHGMB exerts protective effects against renal dysfunction by inhibiting of renal inflammation and fibrosis in NS rats.

关 键 词：Sinkihwan-gamibang Puromycin aminonucleoside Nephrotic syndrome Renal dysfunction NLRP3 inflammasome Fibrosis 

分 类 号：R965[医药卫生—药理学]