Bioactive neolignans and lignans from the roots of Paeonia lactiflora  

作　　者：XIA Huan ZHANG Jing-Fang WANG Ling-Yan XIA Gui-Yang WANG Ya-Nan WU Yu-Zhuo LIN Peng-Cheng XIONG Liang LIN Sheng 

机构地区：[1]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China [2]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China [3]College of Pharmaceutical Sciences,Qinghai University for Nationalities,Xining 810000,China [4]School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China

出　　处：《Chinese Journal of Natural Medicines》2022年第3期210-214,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81773589 and 82073978);Beijing Natural Science Foundation(No.JQ18026);the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province(No.2020-ZJ-Y20).

摘　　要：Two new neolignans and one new lignan(1-3)were obtained from the roots of Paeonia lactiflora.Their structures were unambiguously elucidated based on extensive spectroscopic analysis,single-crystal X-ray crystallography,and the calculated and experimental electronic circular dichroism(ECD)spectra.Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC.Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1(hCES2Al)with an IC_(50) value of 7.28±0.94 μmol·L^(-1).

关 键 词：Paeonia lactiflora NEOLIGNAN Lignan Human carboxylesterase 2A1 

分 类 号：R284.1[医药卫生—中药学]