New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium Koreanuin  

作　　者：ZHAO Yu-Dan ZHANG Xin YANG Wan-Yue ZHANG Rui-Qi MU Lin-Tong HAN Ling LV Chong-Ning LU Jin-Cai 

机构地区：[1]School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Liaoning Provincial Key Laboratory of TCM Resources Conservation and Development,Shenyang Pharmaceutical University,Shenyang 110016,China [3]NERCfor the Pharmaceutics of Traditional Chinese Medicines,Benxi 117004,China

出　　处：《Chinese Journal of Natural Medicines》2022年第3期221-228,共8页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81673548 and U20A20407);Liaoning Revitalization Talents Program(No.XLYC1902119).

摘　　要：Four new prenylflavonoid glycosides,namely koreanoside H-K(1-4),together with eleven known ones(5-15)were isolated from the leaves of Epimedium koreanum Nakai.Their structures were elucidated by ID NMR,2D NMR,HR-ESI-MS,IR and UV.The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives.It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties,which were two extremely rare sugar units from the genus Epimedium.The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line.Compounds 1,2 and 4 showed significant anti-pulmonary fibrosis activities.

关 键 词：Epimedium koreanum Prenylflavonoid glycoside Anti-pulmonary fibrosis 

分 类 号：R284.1[医药卫生—中药学]