羟氯扎胺与左旋咪唑联合用药的研究进展  

Research progress of oxyclozanide combined with levamisole

作　　者：陈玲玲 申涵露 张东辉 张继瑜[1] 周绪正[1] CHEN Ling-ling;SHEN Han-lu;ZHANG Dong-hui;ZHANG Ji-yu;ZHOU Xu-zheng(Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sceiences/Key Laboratory of Veterinary Pharmaceutical Development,Ministry of Agriculture and Rural Affairs/Key Laboratory of New Animal Drug Project of Gansu Province,Lanzhou 730050,China)

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所农村农业部兽药创新重点实验室甘肃省新兽药工程重点实验室,甘肃兰州730050

出　　处：《中国兽医科学》2022年第3期372-379,共8页Chinese Veterinary Science

基　　金：国家现代农业产业技术体系(CARS-37);甘肃省科技计划项目(20JR10RA023)。

摘　　要：羟氯扎胺属于水杨酰苯胺类抗寄生虫类药物,主要用于牛、绵羊、山羊体内肝片吸虫的防治。左旋咪唑属于合成噻唑类化合物的衍生物,用于动物体内线虫的治疗以及免疫能力的增强。将这两种高效、低毒的化学类抗寄生虫药物联合应用,能够实现吸虫和线虫的同时控制,扩大抗虫谱,提高药效。本文就羟氯扎胺左旋咪唑复方制剂及其联合用药的临床药效、毒理学、含量分析方法、药代动力学以及残留消除研究进行综述,以期为相关复方制剂在国内的开发及应用提供参考。Oxyclozanide is an anti-parasitic drug of the salicylanilide and is mainly used for the control of liver flukes in cattle and sheep.Levamisole is a derivative of synthetic thiazole compound used for the treatment of nematodes in animals and for immune enhancement.The combination of the these two highly-effective,low-toxicity chemical antiparasitic drugs can achieve simultaneous control of trematodes and nematodes,expanding the spectrum of anthelmintic activity and improving efficacy.This paper reviews oxyclozanide-levamisole compounded formulations,clinical efficacy in combined treatment,toxicology,content analysis methods,pharmacokinetics and residue elimination studies,with a view to providing a reference for the development and application of related compounded formulations in China.

关 键 词：羟氯扎胺 左旋咪唑 临床药效 毒理学 药代动力学 残留消除 

分 类 号：S859.795[农业科学—临床兽医学]