Fine-tuning hydroxylamines as single-nitrogen sources for Pd(0)-catalyzed diamination of o-bromo(or chloro)-biaryls  

作　　者：Pin Ding Lingbo Han Jiaxing Bai Jingjing Liu Xinjun Luan 

机构地区：[1]Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education,College of Chemistry&Materials Science,Northwest University,Xi’an 710127,China

出　　处：《Science China Chemistry》2022年第4期686-693,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21925108,22171225)。

摘　　要：Transition metal-catalyzed diamination by hydroxylamines is a common approach for making three-membered aziridines,while its use for building the larger N-heterocycles is still underdeveloped.Herein,we report an efficient Pd(0)-catalyzed intermolecular[4+1]annulation of o-bromo(or chloro)-biaryls with bifunctional secondary hydroxylamines for the one-step assembly of synthetically useful carbazoles.Noteworthily,a linchpin for this domino reaction was the judicious selection of both the amino-sources and Pd(0)-catalysts for enabling the prerequisite oxidative addition of aryl halides to Pd(0)-species in the presence of hydroxylamines with a labile N-O bond.

关 键 词：HYDROXYLAMINES diamination o-halobiaryls CARBAZOLES palladium 

分 类 号：O626[理学—有机化学]