Visible-light-induced,autopromoted nickel-catalyzed threecomponent arylsulfonation of 1,3-enynes and mechanistic insights  

作　　者：Duo-Duo Hu Qian Gao Jing-Cheng Dai Ru Cui Yuan-Bo Li Yuan-Ming Li Xiao-Guo Zhou Kang-Jie Bian Bing-Bing Wu Kai-Fan Zhang Xi-Sheng Wang Yan Li 

机构地区：[1]Hefei National Laboratory for Physical Sciences at the Microscale,Department of Chemistry,Center for Excellence in Molecular Synthesis of CAS,University of Science and Technology of China,Hefei 230026,China [2]Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemical Physics,University of Science and Technology of China,Hefei 230026,China

出　　处：《Science China Chemistry》2022年第4期753-761,共9页中国科学（化学英文版）

基　　金：supported by the National Science Foundation of China(21602213,21971228)。

摘　　要：A light-induced,nickel-catalyzed three-component arylsulfonation of 1,3-enynes in the absence of photocatalyst is reported.This methodology exhibited mild conditions,broad scope and high efficiency,and its synthetic utility has been demonstrated by a concise total synthesis of sulfone-containing drug molecule.Detailed mechanistic studies indicated that this light induced nickel catalysis is autopromoted by in situ produced allene,which plays a key role as co-ligand in the photoactive excited state Ni(Ⅰ)species for the LMCT process.The detailed elucidation of this light-induced nickel catalytic cycle may shed some lights on the exploitation of new catalytic activity and establishment of novel methods.

关 键 词：LIGHT-INDUCED autopromoted ligand to metal charge transfer nickel ALLENE 

分 类 号：O621.251[理学—有机化学]