抗反转录病毒治疗下HIV-1感染者病毒持续低水平复制的研究进展  

Progress of research in HIV-1 infected patients with persistent low-level viral replication under antiretroviral therapy

作　　者：孙晓[1,2] 张彤 韩晓旭 SUN Xiao;ZHANG Tong;HAN Xiaoxu(NHC Key Laboratory of AIDS Immunology(China Medical University),Shenyang 110001,China;National Clinical Research Center for Laboratory Medicine,The First Affiliated Hospital of China Medical University,Shenyang 110001)

机构地区：[1]国家卫生健康委员会艾滋病免疫学重点实验室(中国医科大学),沈阳110001 [2]国家医学检验临床医学研究中心中国医科大学附属第一医院,沈阳110001

出　　处：《中国艾滋病性病》2022年第3期360-363,共4页Chinese Journal of Aids & STD

基　　金：国家自然科学基金(81871637)。

摘　　要：抗反转录病毒治疗可有效抑制HIV的复制,使感染者实现病毒学抑制,但部分感染者在实现病毒学抑制后发生低病毒血症,对患者的治疗效果带来不良影响,受到临床普遍重视。然而,目前对低病毒血症的病毒来源及形成机制、病毒的进化及对预后的影响认识还不统一。本文就低病毒血症对预后影响及形成机制和分子进化规律现状进行综述,为更好地管理与治疗低病毒血症患者提供参考。Antiretroviral therapy can effectively inhibit the replication of HIV and make infected persons achieve viral suppression.However,a low-level viremia(LLV)can be detected among some patients after achieving viral suppression,which may impact treatment effectiveness and has aroused clinicians’concern.Furthermore,there is currently limited information regarding the pathogenetic mechanism of LLV,its impact on prognosis,and viral evolution.The review summarized the recent progress on the prognosis,pathogenetic mechanism,and molecular evolution of LLV,aiming to improve the management and treatment of HIV-1 infected patients with LLV.

关 键 词：1型艾滋病病毒 低病毒血症 病毒学失败 进化 抗病毒治疗 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]