重组人脑利钠肽治疗高龄急性心肌梗死合并泵衰竭的效果观察  

Effects of recombinant human brain natriuretic peptide on elderly patients with acute myocardial infarction complicated by pump failure

作　　者：牛靖[1] 赵云[1] 王磊 Niu Jing;Zhao Yun;Wang Lei(Department of Cardiovascular MedicineⅢ,the First People’s Hospital of Nanyang,Nanyang 473000,China)

机构地区：[1]河南省南阳市第一人民医院心血管内三科,473000

出　　处：《中国实用医刊》2022年第2期94-97,共4页Chinese Journal of Practical Medicine

摘　　要：目的:探讨重组人脑利钠肽治疗高龄急性心肌梗死合并泵衰竭的临床效果。方法:抽取2019年6月至2021年6月南阳市第一人民医院收治的180例高龄急性心肌梗死合并泵衰竭患者,依据双盲法分为干预组(90例)与对照组(90例)。对照组给予常规药物治疗,干预组在常规药物治疗基础上给予重组人脑利钠肽治疗。观察并比较两组患者干预后的临床疗效、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心房内经(LAD)及相关实验室检查指标变化。结果:干预组患者临床治疗有效率高于对照组( P<0.05);治疗后,干预组LVEF水平高于对照组,LVEDD、LAD水平低于对照组( P<0.05),两组患者去甲肾上腺素(NE)、内皮素-1(ET-1)、抗利尿激素(ADH)及血肌酐(Cr)水平降低( P<0.05),干预组血清NE、ET-1水平改善程度优于对照组( P<0.05)。 结论:重组人脑利钠肽治疗高龄急性心肌梗死合并泵衰竭患者可积极改善患者LVEF、LVEDD及LAD水平,提高临床治疗效果,对患者心肌功能、心室功能的保护与提高有积极作用。Objective To explore the effect of recombinant human brain natriuretic peptide on elderly patients with acute myocardial infarction complicated by pump failure.Methods A total of 180 elderly patients with acute myocardial infarction complicated by pump failure treated in the First People’s Hospital of Nanyang from June 2019 to June 2021 were divided into intervention group(90 cases)and control group(90 cases)according to double-blind method.The control group was treated with the conventional drugs,the intervention group was treated with recombinant human brain natriuretic peptide based on the conventional drugs.The clinical outcomes,left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDd),left atrial internal diameter(LAD)and related laboratory test indexes before and after treatment were observed and compared between the two groups.Results The clinical effective rate of the intervention group was higher than that of the control group(P<0.05);after the treatment,LVEF levels were higher and LVEDd and LAD levels were lower in the intervention group than those in the control group(P<0.05),the levels of norepinephrine(NE),endothelin-1(ET-1),antidiuretic hormone(ADH)and serum creatinine(CR)in the two groups decreased significantly(P<0.05),the improvement of serum NE and ET-1 in the intervention group was significantly better than that in the control group(P<0.05).Conclusions In the clinical treatment of elderly patients with acute myocardial infarction complicated by pump failure,recombinant human brain natriuretic peptide can actively improve the levels of LVEF,LVEDd and LAD,improve the clinical treatment effect,and play a very positive role in the protection and improvement of myocardial function and ventricular function.

关 键 词：心肌梗死 泵衰竭 重组人脑利钠肽 心肌重构 

分 类 号：R542.22[医药卫生—心血管疾病] R541.6[医药卫生—内科学]