VGLL4基因多态性与非贲门胃癌遗传易感性的关系  

Association analysis between SNPs in VGLL4 and risk of non-cardia gastric cancer

作　　者：杨霞 董文杰[1] 高芳[2] 武金宝[3] 马立聪 党彤[3] 孟宪梅[3] 贾彦彬[1,3,4] Yang Xia;Dong Wenjie;Gao Fang;Wu Jinbao;Ma Licong;Dang Tong;Meng Xianmei;Jia Yanbin(School of Basic Medicine and Forensic Medicine,The Second Affiliated Hospital of Baotou Medical College,Baotou 014030;School of Medical Technology and Anesthesiology,The Second Affiliated Hospital of Baotou Medical College,Baotou 014030;Inner Mongolia Institute of Digestive Diseases,The Second Affiliated Hospital of Baotou Medical College,Baotou 014030;School of Nursing,Baotou Medical College,Baotou 014060)

机构地区：[1]包头医学院基础医学与法医学院,包头014060 [2]包头医学院技术与麻醉学院,包头014060 [3]包头医学院第二附属医院内蒙古消化病研究所,包头014030 [4]包头医学院护理学院,包头014060

出　　处：《安徽医科大学学报》2022年第4期636-639,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81650017);内蒙古自治区自然科学基金项目(编号:2020LH08004)。

摘　　要：目的探讨残留样蛋白质家族成员4(VGLL4)基因单核苷酸多态性(SNP)与非贲门胃癌发病风险的关系。方法采用病例-对照关联研究的方法,在包头地区汉族人群中收集450例经病理学确诊的非贲门胃癌病例,同时收集450例正常体检人群作为对照;采用聚合酶链式反应(PCR)-限制性片段长度多态性(RFLP)技术对VGLL4 SNP rs1803489、rs7617620、rs13078528位点进行基因分型。结果在包头地区汉族人群中VGLL4 rs1803489与非贲门胃癌的发病风险关联,与GG基因型携带者相比,AG基因型携带者非贲门胃癌的发病风险增加(AGvs GG:OR=1.511,95%CI=1.095~2.085);VGLL4 rs7617620、rs13078528与非贲门胃癌的发病风险没有关联。结论在包头地区汉族人群中,VGLL4 rs1803489在非贲门胃癌的发病中起到了一定的作用;VGLL4 rs7617620、rs13078528在非贲门胃癌的发病中不起主要作用。Objective To investigate the associations of the single nucleotide polymorphism(SNP)rs1803489,rs7617620 and rs13078528 in vestigial like family member 4(VGLL 4)gene with the risk of non-cardia gastric cancer.Methods The case-control study design was used.450 cases with non-cardia gastric cancer confirmed by pathology and 450 normal controls were collected in the Han population in Baotou;SNP rs1803489,rs7617620,and rs13078528 in VGLL 4 were genotyped using polymerase chain reaction(PCR)-restriction fragment length polymorphism(RFLP)technology.Results VGLL 4 gene SNP rs1803489 was associated with the risk of non-cardia gastric cancer in the Han population in Baotou.Compared with the carriers of GG genotype,the carriers of AG genotype had a higher risk of non-cardia gastric cancer(OR=1.511,95%CI=1.095-2.085,P<0.05).SNP rs7617620 and rs13078528 were not associated with non-cardia gastric cancer(P>0.05).Conclusion SNP rs1803489 in VGLL 4 may have an effect on the risk of non-cardia gastric cancer in the Han population in Baotou.SNP rs7617620 and rs13078528 may not play a major role in the risk of non-cardia gastric cancer.

关 键 词：残留样蛋白家族成员4 单核苷酸多态性 非贲门胃癌 遗传易感性 

分 类 号：R34[医药卫生—基础医学]