IL-16基因多态性与GDM的关系及对妊娠结局的影响  

Association between IL-16 gene polymorphism and susceptibility to GDM and its influence on pregnancy outcome

作　　者：卓然然 付盼盼 Zhuo Ranran;Fu Panpan(Department of Obstetrics and Gynecology,Hainan Women and Children Medical Center,Haikou 571100,China;Department of Obstetrics and Gynecology,Baota District People′s Hospital,Yan′an City,Yan′an 716000,China)

机构地区：[1]海南省妇女儿童医学中心妇产科,海口571100 [2]陕西省延安市宝塔区人民医院妇产科,716000

出　　处：《国际内分泌代谢杂志》2022年第2期118-123,共6页International Journal of Endocrinology and Metabolism

摘　　要：目的探讨白细胞介素(IL)-16基因多态性与妊娠期糖尿病(GDM)易感性的关联性,并分析其对妊娠结局的影响。方法连续性选取2018年1月至2020年1月海南省妇女儿童医学中心收治的125例GDM患者作为GDM组,另依据1∶1配对原则选取同期、同年龄段、同孕周的125名健康孕妇作为对照组。比较两组基线资料、IL-16基因多态性、血清IL-16水平,并比较GDM不同IL-16基因型患者空腹血糖(FPG)、稳态模型评估-胰岛素抵抗指数(HOMA-IR)、口服葡萄糖耐量试验(OGTT)结果,采用logistic回归方程分析GDM的相关影响因素,比较GDM不同基因型患者妊娠结局。结果GDM组有糖尿病家族史占比(15.20%)高于对照组(4.00%),血清IL-16水平高于对照组(P均<0.05);GDM组IL-16基因rs11556218位点GG基因型占比(12.00%)、等位基因G占比(33.60%)均高于对照组(1.60%、21.20%),P均<0.05;IL-16基因rs11556218位点GG基因型GDM患者FPG、HOMA-IR、OGTT 0、1、2 h血糖值及血清IL-16水平高于TT、TG基因型患者(P均<0.05);有糖尿病家族史、血清IL-16水平升高、IL-16基因rs11556218位点基因型为GG均与GDM的发生显著相关(P均<0.05);rs11556218位点GG基因型会增加GDM患者不良妊娠结局发生率。结论IL-16基因rs11556218位点基因多态性与GDM易感性显著相关,其GG基因型可增加不良妊娠结局发生率。Objective To investigate the relationship between interleukin-16(IL-16)gene polymorphism and susceptibility to gestational diabetes mellitus(GDM),and to analyze its influence on pregnancy outcome.Methods A total of 125 patients with GDM admitted to Hainan Women and Children Medical Center from January 2018 to January 2020 were continuously selected as the GDM group.In addition,125 healthy pregnant women in the same period,the same age,and the same gestational age were selected according to the 1∶1 matching principle as the control group.The baseline data,IL-16 gene polymorphism,and serum IL-16 levels were compared between the two groups.The results of fasting plasma glucose(FPG)and homeostasis model assessment-insulin resistance(HOMA-IR),and oral glucose tolerance test(OGTT)were compared in GDM patients with different IL-16 genotypes.The logistic regression equation was used to analyze the related factors of GDM,and the pregnancy outcomes of patients with different genotypes of GDM were compared.Results The proportion of family history of diabetes in the GDM group(15.20%)was higher than that in the control group(4.00%)(all P<0.05).The proportion of GG genotype(12.00%),proportion of allele G(33.60%)at the rs11556218 locus of IL-16 gene in GDM group were higher than those of control group(1.60%,21.20%),all P<0.05.The FPG,HOMA-IR,OGTT 0,1,2 h blood glucose levels and serum IL-16 levels of GDM patients with GG genotype at rs11556218 locus of IL-16 gene were higher than those of TT and TG patients(all P<0.05).With a family history of diabetes,elevated serum IL-16 levels,and genotype GG at rs11556218 of the IL-16 gene all significantly increased the risk of GDM(P<0.05).The GG genotype at the rs11556218 locus increases the incidence of adverse pregnancy outcomes in patients with GDM.Conclusion The genetic polymorphism of IL-16 gene rs11556218 is significantly related to the susceptibility to GDM,and its GG genotype can significantly increase the incidence of adverse pregnancy outcomes.

关 键 词：妊娠期糖尿病 白细胞介素-16 基因多态性 易感性 妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]