冠心病患者血清BMP6、TGF-β1水平与冠状动脉病变程度的相关性  

Correlation Between Serum Levels of BMP6,TGF-β1 and Severity of Coronary Artery Disease in Patients with Coronary Heart Disease

作　　者：廖占玲 安国印 吴晶晶[1] 陈润祥[1] LIAO Zhan-ling;AN Guo-yin;WU Jing-jing(Suzhou Kowloon Hospital,Shanghai Jiao Tong University School of Medicine,Suzhou Jiangsu 215128)

机构地区：[1]上海交通大学医学院附属苏州九龙医院,江苏苏州215128

出　　处：《医学临床研究》2022年第3期435-438,共4页Journal of Clinical Research

摘　　要：【目的】探讨冠心病(CHD)患者血清骨形态发生蛋白6(BMP6)、转化生长因子-β1(TGF-β1)水平与冠状动脉病变程度的关系。【方法】选取2017年12月至2020年10月本院收治的90例CHD患者(观察组),并选取同期90例体检健康者(对照组)。比较两组血清BMP6、肌酸激酶同工酶(CK-MB)、TGF-β1、心肌肌钙蛋白I(cTnI)水平;分析CHD患者血清BMP6、TGF-β1水平与CK-MB、cTnI的关系及血清BMP6水平与TGF-β1的相关性;比较不同病变支数CHD患者血清BMP6、TGF-β1水平;评估血清BMP6、TGF-β1水平诊断CHD的价值。【结果】观察组患者血清CK-MB、BMP6、cTnI水平高于对照组(P<0.05),TGF-β1水平低于对照组(P<0.05)。CHD患者血清BMP6水平与CK-MB、cTnI呈正相关(P<0.05),与TGF-β1呈负相关(P<0.05);CHD患者血清TGF-β1水平与CK-MB、cTnI呈负相关(P<0.05);随冠状动脉病变支数增加,CHD患者血清BMP6水平逐渐升高(P<0.05),TGF-β1水平逐渐降低(P<0.05);血清BMP6、TGF-β1诊断CHD的曲线下面积(AUC)分别为0.899、0.845,截断值分别为35.36 pg/mL、104.99 pg/mL;两者联合诊断CHD的AUC为0.939,敏感度为86.7%,特异性为90.0%。【结论】CHD患者血清BMP6水平升高,TGF-β1水平降低,均与冠状动脉病变程度有关,两者联合可提高对CHD的诊断价值,值得临床借鉴。【Objective】To investigate the relationship between serum levels of bone morphogenetic protein 6(BMP6)and transforming growth factor beta-1(TGF-β1)in patients with coronary heart disease(CHD).【Methods】90 patients with CHD diagnosed and treated in our hospital from December 2017 to October 2020 were selected as CHD group,and 90 healthy persons in physical examination in the same period were selected as healthy group.Serum BMP6,creatine kinase MB(CK-MB),TGF-β1,cardiac troponin I(cTnI)were compared between the two groups;the relationship between serum BMP6,TGF-β1 levels and CK-MB,cTnI in CHD patients,and the correlation between serum BMP6 levels and TGF-β1 were analyzed;the serum BMP6 and TGF-β1 levels in patients with CHD with different diseased branches were compared;the value of serum BMP6 and TGF-β1 levels in the diagnosis of CHD were evaluated.【Results】Serum CK-MB,BMP6 and cTnI levels in CHD group were higher than those in healthy group(P<0.05),and TGF-β1 levels were lower than healthy group(P<0.05);Serum BMP6 levels in CHD patients were positively correlated with CK-MB and cTnI(P<0.05),and negatively correlated with TGF-β1(P<0.05);serum TGF-β1 levels in CHD patients were negatively correlated with CK-MB and cTnI(P<0.05);with the increase of the number of coronary artery lesions(aggravation),the level of serum BMP6 increased gradually(P<0.05),and the level of TGF-β1 gradually decreased(P<0.05);there was a negative correlation between serum BMP6 level and TGF-β1 in CHD patients(P<0.05);the area under the curve(AUC)of serum BMP6 and TGF-β1 in the diagnosis of CHD was 0.899 and 0.845,the cut-off value was 35.36 pg/mL and 104.99 pg/mL,respectively,the both sensitivity was 88.9%,and specificity was 77.8%and 72.2%respectively;the AUC of the combined diagnosis was 0.939,the corresponding sensitivity was 86.7%,and the specificity was 90.0%.【Conclusion】The level of serum BMP6 in CHD patients is increased,and the level of TGF-β1 is decreased,they are related to the severity of coronary artery

关 键 词：冠心病 骨形态发生蛋白质类/血液 转化生长因子β1/血液 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]