地黄饮子辅助治疗肾虚髓减型2型糖尿病合并轻度认知功能障碍的临床疗效观察  

Clinical effect observation of Dihuangyinzi in adjuvant treatment of deficiency of kidney and marrow syndrome type 2 diabetes mellitus with mild cognitive impairment

作　　者：李全[1] 贾斯婷 关慧波[2] LI Quan;JIA Si-ting;GUAN Hui-bo(First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150040,China;Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《时珍国医国药》2022年第2期410-412,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81774197);黑龙江省自然科学基金(LH2019H052);中医药防治心脑慢性疾病机制研究科技创新团队项目(2019TD01)。

摘　　要：目的观察地黄饮子辅助治疗肾虚髓减型2型糖尿病(T2DM)合并轻度认知功能障碍(MCI)患者的临床疗效观察。方法将64例肾虚髓减型T2DM合并MCI患者随机分为地黄饮子辅助组和多奈哌齐组。根据病情制定整体式降糖方案,多奈哌齐组给予口服盐酸多奈哌齐片治疗,地黄饮子辅助组在此基础上予以地黄饮子辅助治疗,4周一个疗程,共治疗2个疗程。治疗后,比较两组患者血糖相关指标、MMSE评分、MoCA评分以及中医证候积分的变化,并对比两组疗效。结果2个疗程后,两组血糖相关指标与治疗前比较明显降低(P<0.05),组间对比显示FBG、2hPBG、HbA1C均无统计学差异(P>0.05);两组患者MMSE、MoCA量表评分均明显改善(P<0.05),且两组比较地黄饮子辅助组具有明显统计学意义(P<0.05)。地黄饮子辅助组治疗后中医证候积分显著降低(P<0.01)。地黄饮子辅助组总有效率90.63%,优于多奈哌齐组的71.88%(P<0.05)。结论地黄饮子辅助治疗肾虚髓减型2型糖尿病合并轻度认知功能障碍临床疗效显著,能在稳定血糖基础上有效改善患者的认知功能障碍,且安全性良好。Objective To observe the clinical efficacy of Dihuangyinzi in adjuvant treatment of type 2 diabetes mellitus(T2DM)combined with mild cognitive impairment(MCI).Methods Sixty-four patients with T2DM combined with MCI were randomly divided into Rehmannia glutinosa adjuvant group and donepezil group.According to the condition of the disease,a holistic hypoglycemic plan was formulated.The donepezil group was given oral donepezil hydrochloride tablets,and the Rehmannia glutinosa adjuvant group was given adjuvant Rehmannia decoction on this basis.A course of treatment was 4 weeks for a total of 2 courses.After treatment,the changes in blood glucose-related indicators,MMSE score,MoCA score and TCM syndrome score between the two groups were compared,and the efficacy of the two groups was compared.Results After 2 courses of treatment,the blood glucose-related indexes of the two groups were significantly lower than before treatment(P<0.05).The comparison between the groups showed that FBG,2hPBG,and HbA 1C were not statistically different(P>0.05);the two groups of patients were MMSE,MoCA The scale scores were significantly improved(P<0.05),and the Rehmannia glutinosa auxiliary group was statistically significant compared with donepezil group(P<0.05).The scores of TCM syndromes in the adjuvant group of Rehmannia glutinosa decreased significantly after treatment(P<0.01).The total effective rate of Rehmannia glutinosa adjuvant group was90.63%,which was better than 71.88%of donepezil group(P<0.05).Conclusion Dihuangyinzi has a significant clinical effect in adjuvant treatment of type 2 diabetes mellitus with reduced kidney marrow and mild cognitive dysfunction.It can effectively improve the cognitive dysfunction of patients on the basis of stabilizing blood sugar,and has good safety.

关 键 词：地黄饮子 肾虚髓减型 中医药辅助治疗 2型糖尿病合并轻度认知功能障碍 临床疗效 

分 类 号：R259[医药卫生—中西医结合]