基于肠道菌群探讨“饮食自倍,肠胃乃伤”在代谢性疾病发生中的作用  

Discussion“irregular diet,gastrointestinal injury”role in the development of metabolic diseases based on intestinal flora

作　　者：罗宏扬 周昕[1] 沈涛[1] 王彤 吴粤 LUO Hong-yang;ZHOU Xin;SHEN Tao;WANG Tong;WU Yue(School of Basic Medical,Chengdu University of Traditional Chinese Medicine,Chengdu 611137 China)

机构地区：[1]成都中医药大学基础医学院,四川成都611137

出　　处：《时珍国医国药》2022年第2期425-428,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81703844);四川省科技厅苗子工程重点项目(20MZGC0241)。

摘　　要：中医认为,若饮食违背了正常规律,则会损伤脾胃功能,导致精微输布传导失司,是代谢性疾病的重要病因,但其具体靶位和机制尚未探明。近年研究表明,“饮食不节”所致的肠道菌群紊乱、肠黏膜屏障受损是“肠胃乃伤”的本质特点。文章从肠道菌群出发,对“饮食自倍,肠胃乃伤”的物质基础进行科学阐释,并论述调节肠道菌群对肥胖、糖尿病、非酒精性脂肪肝等代谢性疾病产生的作用,期望通过现代科学技术知识来描述和阐释中医学理论。Traditional Chinese medicine believes that if the diet goes against the normal rules,it will damage the function of the spleen and stomach,and loss of fine distribution conduction,which is an important factor in the occurrence of metabolic diseases,but its specific target and mechanism have not been identified.Recent studies have shown that the disorder of intestinal flora and the damage of intestinal mucosal barrier caused by"irregular diet"are the essential characteristics of"gastrointestinal injury",which is consistent with the pathogenesis of metabolic diseases.Starting with intestinal flora,this paper scientifically explains the material basis of"Irregular diet leads to the injury of intestines and stomach"and discusses the application of regulating intestinal flora in the prevention and treatment of metabolic diseases such as obesity,diabetes,non-alcoholic fatty liver and so on.We hope to use modern scientific and technical knowledge to describe and explain the theory of traditional Chinese medicine.

关 键 词：饮食自倍 肠胃乃伤 代谢性疾病 肠道菌群 

分 类 号：R259[医药卫生—中西医结合] R2-031[医药卫生—中医内科学]