沙库巴曲沙坦类药-药共晶研究进展  

Research Progress of Drug-drug Cocrystals of Sacubitril and Sartans

作　　者：赵丽丽 翟真真 朱林元 李雯[1,3] ZHAO Lili;ZHAI Zhenzhen;ZHU Linyuan;LI Wen(School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China;School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Henan Province & Key Laboratory of Technology of Drug Preparation,Collaborative Innovation Center of New Drug Research and Safety Evaluation and Ministry of Education & Key Laboratory of Henan Province for Drug Quality and Evaluation,Zhengzhou 450001,China)

机构地区：[1]郑州大学药学院,郑州450001 [2]中国药科大学药学院,南京210009 [3]药物关键制备技术教育部重点实验室、新药创制与药物安全性评价河南省协同创新中心和河南省药品质量控制与评价重点实验室,郑州450001

出　　处：《医药导报》2022年第5期664-668,共5页Herald of Medicine

基　　金：河南省科技厅产学研项目(15210700041)。

摘　　要：开发新型药-药共晶的临床应用价值是值得期待的研究领域。近年来,多个药-药共晶药物获得美国和我国药品审评中心上市批准,这使得药-药共晶药物研究成为药物晶型领域的研究热点,药-药共晶成为多靶点药物开发的新思路。沙库巴曲可与多种沙坦类药物在分子水平上形成药-药共晶,该文对沙库巴曲-沙坦类药物共晶的作用机制、结构特征和制备方法等发展情况进行综述。The clinical application value of developing new drug-drug cocrystals is a field worth looking forward to researching.In recent years,a number of drug-drug cocrystals have been approved for listing by the drug examination centers of the United States and China,which makes the research on drug-drug cocrystals become a hot issue in the field of drug crystal form research,and drug-drug cocrystals has become a new idea of multi-target drug development.Sacubitril can form cocrystals with a variety of sartan drugs at the molecular level.Furthurmore,the development of the preparation methods,structural characteristics and of metabolism is reviewed.In this paper,the mechanism of action,structural characteristics,and preparation methods of sacubitril-sartans cocrystals were reviewed.

关 键 词：沙库巴曲 沙坦类药物 药-药共晶 多靶点药物 

分 类 号：R972.1[医药卫生—药品] R969[医药卫生—药学]