磺脲类降糖药与抗菌药物潜在不良药物相互作用的处方分析  

Analysis of the Prescriptions of Potential Adverse DrugInteractions Between Sulfonylurea Hypoglycemic Agents and Antibacterial Drugs

作　　者：程军[1] 汪龙[1] 张冠军[1] 朱玲娜[1] CHENG Jun;WANG Long;ZHANG Guanjun;ZHU Lingna(Department of Pharmacy,the Third People's Hospital of Bengbu City, Anhui Province,Bengbu 233000,China)

机构地区：[1]安徽省蚌埠市第三人民医院药学部,蚌埠233000

出　　处：《医药导报》2022年第5期708-712,共5页Herald of Medicine

基　　金：2020年度蚌埠市级科技创新指导类项目(20200322)。

摘　　要：目的分析磺脲类降糖药与抗菌药物潜在不良药物相互作用(pADIs),促进合理用药。方法通过某院合理用药软件系统抽取2018年1月1日—2020年12月31日磺脲类降糖药联合使用抗菌药物的所有门诊处方,鉴别潜在pADIs,对pADIs危险严重性进行分级,并对国内外数据库收载的磺脲类降糖药与抗菌药物相互作用致不良反应个案报道进行复习。结果共收集到磺脲类降糖药联合使用抗菌药物处方155张,发生pADIs处方26张,分别为喹诺酮类药物21张(左氧氟沙星19张,莫西沙星2张)和克拉霉素5张,其危险程度分级均为“严重”。检索出磺脲类降糖药与抗菌药物相互作用致不良反应个案报道28篇共34例患者,男21例,女13例,年龄50~94岁,平均71岁,均为低血糖反应,使用抗菌药物5 d内出现低血糖31例(91.2%)。结论该院磺脲类降糖药与抗菌药物存在pADIs,需要加强监测和干预,尤其是用药5 d内的老年患者。Objective To analyze potential adverse drug interactions(pADIs)between sulfonylurea hypoglycemic agents and antibacterial drugs,and to promote rational drug use.Methods Outpatient prescriptions of using sulfonylurea hypoglycemic agents in combination with antibacterial drugs from January 1,2018 to December 31,2020 through rational drug software system in a hospital were surveyed and pADIs were identified and classified into categories of potential clinical outcome.The case reports of adverse reactions between sulfonylurea hypoglycemic agents and antibacterial drugs were collected and analyzed,from the databases of CNKI,VIP,Wanfang and PubMed.Results A total of 155 prescriptions of sulfonylurea hypoglycemic agents and antibacterial drugs were enrolled.There were 26 prescriptions for pADIs,including 21 quinolone drugs prescriptions(19 levofloxacin prescriptions and 2 moxifloxacin prescriptions)and 6 clarithromycin prescriptions.The level of pADIs was determined by“severity”.A total of 28 reports involving 34 patients of adverse reactions caused by interaction between sulfonylurea hypoglycemic agents and antibacterial drugs were included.Of all the 34 patients,21 were male and 13 were female with age from 50 to 94 and the average age was 71.All cases occurred hypoglycemia.Hypoglycemia induced by between sulfonylurea hypoglycemic agents and antibacterial drugs mainly attackked within 5 days(n=31,91.2%).Conclusion There were pADIs between sulfonylurea hypoglycemic agents and antibacterial drugs in the hospital.It is necessary for hospital to strengthen monitoring and intervention to reduce the risk of medication,especially in the elderly patients within 5 days of combination therapy.

关 键 词：磺脲类降糖药 抗菌药物 不良药物相互作用 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学]