免疫抑制剂联合利妥昔单抗治疗重症获得性血友病完全缓解1例并文献复习  

Immunosuppressant combined with rituximab in the treatment of severe acquired haemophilia:a case of complete remission report and literature review

作　　者：谢春红 韦敏[1] 刘琴[1] 陈磊 黄锦雄[1] XIE Chunhong;WEI Min;LIU Qin;CHEN Lei;HUANG Jinxiong(Hematology Department,Liuzhou People's Hospital,Liuzhou 545006,China)

机构地区：[1]柳州市人民医院血液内科,广西柳州545006

出　　处：《临床医学研究与实践》2022年第12期1-4,9,共5页Clinical Research and Practice

摘　　要：1例43岁男性因左下肢肿痛10 d,右上肢肿胀、瘀斑5 d入院,诊断为重症获得性血友病(AH)。入院后予甲泼尼龙联合环磷酰胺抑制免疫治疗,患者症状好转后出院并继续规律服用环磷酰胺及甲泼尼龙。出院2个月后患者症状再发,予改为泼尼松联合环磷酰胺抑制免疫治疗,患者症状无明显好转,加用利妥昔单抗联合环磷酰胺及泼尼松抑制免疫治疗,病情好转后出院。随访1年后患者症状无再发。A 43-year-old man was admitted in the hospital after 10 d of swelling and pain in the left lower limb and 5 d of swelling and ecchymosis in the right upper limb.The patient was diagnosed as severe acquired haemophilia(AH).After admission,the patient was treated with methylprednisolone combined with cyclophosphamide immunosuppressive therapy.After symptom improvement,the patient discharged and continued to take cyclophosphamide and methylprednisolone regularly.Two months after discharge,the symptoms recurred and the treatment method were changed to prednisone combined with cyclophosphamide immunosuppressive therapy,but the symptoms did not improve significantly.Then rituximab combined with cyclophosphamide and prednisone immunosuppressive therapy was additionally given,and the patient discharged after the condition improved.There was no recurrence of symptoms after 1 year of follow-up.

关 键 词：利妥昔单抗 免疫抑制剂 获得性血友病 

分 类 号：R554.1[医药卫生—血液循环系统疾病]