地塞米松磷酸钠注射液治疗上呼吸道感染的临床效果与安全性  

Clinical effect and safety of dexamethasone sodium phosphate injection in the treatment of upper respiratory tract infection

作　　者：司永奇 SI Yongqi(Internal Medicine Department,the First Branch of Central Hospital of Jiaozuo Coal Industry(Group)Co.,Ltd,Jiaozuo 454191,China)

机构地区：[1]焦作煤业(集团)有限责任公司中央医院一分院内科,河南焦作454191

出　　处：《临床医学研究与实践》2022年第12期48-51,共4页Clinical Research and Practice

摘　　要：目的分析地塞米松磷酸钠注射液治疗上呼吸道感染的临床效果与安全性。方法选择2019年3月至2021年3月我院收治的420例上呼吸道感染患者作为研究对象,按照红绿双色球法将其分为对照组与研究组,每组210例。对照组给予常规治疗,研究组给予地塞米松磷酸钠注射液+常规治疗。比较两组的临床症状消失时间、炎症因子水平、免疫功能指标、治疗效果、不良反应发生情况以及肺功能指标。结果研究组的发热、咽痛、咳嗽及流涕消失时间均短于对照组,差异具有统计学意义(P<0.05)。治疗7 d后,研究组的IL-1β、CRP及PCT水平低于对照组,IL-10水平高于对照组,差异具有统计学意义(P<0.05)。治疗7 d后,研究组的CD3+、CD4+及CD4+/CD8+高于对照组,CD8+低于对照组,差异具有统计学意义(P<0.05)。研究组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。研究组的不良反应总发生率低于对照组,差异具有统计学意义(P<0.05)。治疗7 d后,研究组的FVC、FEV1及FEV1/FVC高于对照组,差异具有统计学意义(P<0.05)。结论地塞米松磷酸钠注射液治疗上呼吸道感染的效果显著,可改善患者的临床症状以及免疫功能,减轻炎症反应,促进肺功能恢复,且不良反应少,值得临床推广。Objective To analyze the clinical effect and safety of dexamethasone sodium phosphate injection in the treatment of upper respiratory tract infection.Methods A total of 420 patients with upper respiratory tract infection admitted in our hospital from March 2019 to March 2021 were selected as the research objects and divided into control group and study group according to the red-green bicolor method,with 210 cases in each group.The control group was given routine treatment,and the study group was given dexamethasone sodium phosphate injection+routine treatment.The clinical symptom disappearance time,inflammatory factors levels,immune function indexes,therapeutic effect,occurrence of adverse reactions and lung function indexes were compared between the two groups.Results The disappearance time of fever,sore throat,cough and runny nose in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After 7 d of treatment,the levels of IL-1β,CRP and PCT in the study group were lower than those in the control group,IL-10 level was higher than that in the control group,and the differences were statistically significant(P<0.05).After 7 d of treatment,CD3+,CD4+and CD4+/CD8+in the study group were higher than those in the control group,while CD8+was lower than that in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).After 7 d of treatment,FVC,FEV1 and FEV1/FVC in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Dexamethasone sodium phosphate injection has a significant effect in the treatment of upper respiratory tract infection,it can improve the

关 键 词：上呼吸道感染 地塞米松磷酸钠注射液 不良反应 免疫功能 肺功能 

分 类 号：R927.11[医药卫生—药学]