宁夏地区老年女性原发性骨质疏松症维生素D受体基因多态性研究  

Study on gene polymorphism of vitamin D receptor in elderly female patients with primary osteoporosis in Ningxia

作　　者：马宗军[1] 吴鹏[1] 丁小力[1] 陈振[1] 于辛酉[2] 张小羽[3] MA Zongjun;WU Peng;DING Xiaoli;CHEN Zhen;YU Xinyou;ZHANG Xiaoyu(General Hospital of Ningxia Medical University,Yinchuan 750004,China;Prenatal Diagnosis Center,General Hospital of Ningxia Medical University,Yinchuan 750004,Chian;Department of Radiology,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院骨科,宁夏银川750004 [2]宁夏医科大学总医院产前诊断中心,宁夏银川750004 [3]宁夏医科大学总医院放射科,宁夏银川750004

出　　处：《宁夏医学杂志》2022年第4期296-298,共3页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(2020AAC03396)。

摘　　要：目的探讨宁夏地区老年女性原发性骨质疏松症与维生素D受体基因(VDR)基因多态性的相关性。方法应用聚合酶链反应限制性片段长度多态性技术(PCR-RFLP)分析230例原发性骨质疏松症患者血液样本VDR基因型,探讨宁夏地区老年女性与VDR基因多态性的相关性。结果230例患者的VDR受体基因型频率分布均符合Hardy-Weinberg定律,宁夏老年女性骨质疏松症的VDR受体基因型频率bb型、Bb型、BB型分别占78.69%、19.72%、1.59%。结论宁夏地区老年女性原发性骨质疏松症患者与VDR基因多态性具有相关性。Objective To investigate the distribution of gene polymorphism of vitamin D receptor(VDR)among old female patients with primary osteoporosis(PO)in Ningxia.Methods 230 specimens of female outpatients were collected,according to the diagnostic criteria of osteoporosis.The genotype of VDR was measured by polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP).Results The distribution of nucleotide polymorphism in VDR was paralleled with the Hardy-Weinberg rule.Genotype bb,Bb and BB in Old female patients with primary osteoporosis in Ningxia were 78.69%,19.72%and 1.59%.Conclusion There’s a significant difference of VDR gene polymorphism in Ningxia regions.

关 键 词：维生素D受体 基因多态性 骨质疏松症 

分 类 号：R591.44[医药卫生—内科学]