红细胞分布宽度和血管生成素2及缺氧诱导因子1α对慢性心力衰竭远期预后的影响  

Effect of red blood cell distribution width, serum Ang-2 and HIF-1α on long-term outcomes in CHF patients

作　　者：关杨[1] 李红[1] 郭飞[1] 刘新民[1] 张骞[1] 吕强[1] Guan Yang;Li Hong;Guo Fei;Liu Xinmin;Zhang Qian;Lü Qiang(Heart failure center,Department of Cardiology,Affiliated Beijing Anzhen Hospital of Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院心内科心力衰竭中心,100029

出　　处：《中华老年心脑血管病杂志》2022年第4期393-395,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家自然科学基金(8207020861)。

摘　　要：目的探究外周血红细胞分布宽度(RDW)、血管生成素2(Ang-2)、缺氧诱导因子1α(HIF-1α)表达水平对慢性心力衰竭(心衰)患者远期预后的影响。方法选择慢性心衰急性发作患者287例,根据远期预后情况分为存活组244例和死亡组43例,比较2组血清Ang-2、RDW、HIF-1α、B型钠尿肽(BNP)水平,采用ROC曲线分析预测价值。结果与存活组比较,死亡组血清Ang-2、RDW、HIF-1α、BNP水平明显升高(P=0.000)。血清Ang-2、RDW、HIF-1α水平与慢性心衰患者远期预后呈正相关(r=0.542,r=0.443,r=0.477,P=0.000),是慢性心衰患者远期不良预后的危险因素(P<0.01)。3项指标联合检测预测慢性心衰患者远期预后的曲线下面积为0.974(95%CI:0.947~1.000),明显高于各项指标单独检测(P<0.05)。结论血清Ang-2、RDW、HIF-1α增加是慢性心衰患者远期不良预后的危险因素,3项指标联合检测对慢性心力衰竭患者远期预后有较高的预测价值。Objective To study the effect of RDW,serum Ang-2 and HIF-1α levels on the long-term outcomes in CHF patients.Methods Two hundred and eighty-seven CHF patients were divided into survival group(n=244) and death group(n=43) according to their long-term outcomes.Their serum Ang-2,HIF1α and NT-proBNP levels, RDW were measured.The value of serum Ang-2 and HIF-1α levels and RDW for predicting the long-term outcomes in CHF patients was analyzed by ROC curve analysis.Results The serum Ang-2,HIF-1α and NT-proBNP levels and RDW were significantly higher in death group than in survival group(P<0.01).The serum Ang-2 and HIF-1α levels and RDW were positively related with the long-term outcomes in CHF patients and were risk factors for the long-term poor outcomes in CHF patients(r=0.542,r=0.443,r=0.477,P=0.000).The AUC of serum Ang-2 and HIF-1α levels and RDW measured in combination was 0.974(95%CI:0.947~1.000),and significantly larger than that of serum Ang-2 and HIF-1αlevels and RDW measured respectively for predicting the long-term outcomes in CHF patients(P<0.05).Conclusion Elevated serum Ang-2 and HIF-1α levels and RDW are risk factors for the long-term poor outcomes in CHF patients.The value of serum Ang-2 and HIF-1α levels and RDW measured in combination for predicting the long-term outcomes in CHF patients is higher than that of serum Ang-2 and HIF-1α levels and RDW measured respectively.

关 键 词：红细胞 血管生成素2 缺氧诱导因子1 Α亚基 预后 

分 类 号：R541.6[医药卫生—心血管疾病]