基于“热极成毒”理论探讨肺“炎-癌转化”与防治思路  

Discussion on “inflammatory in flammation-cancer transformation” and prevention and treatment of lung cancer based on the theory of “heat polarized toxicity”

作　　者：张传龙 姜晓晨 庞博[1] 李奕 高梦琦[2] 花宝金[1] ZHANG Chuanlong;JIANG Xiaochen;PANG Bo;LI Yi;GAO Mengqi;HUA Baojin(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Shandong university of traditional Chinese medicine,Jinan 250000,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]山东中医药大学

出　　处：《北京中医药大学学报》2022年第3期291-295,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(No.81873399);中国中医科学院科技创新工程肿瘤学重大攻关项目(No.CI2021A01805)。

摘　　要：“炎-癌转化”是炎症相关性疾病从炎症到癌症发生、发展、转化过程的总称,中医学多从火、热、毒来认识炎症,阻断肺“炎-癌转化”进程,可延缓肺癌发生发展。基于“热极成毒”理论并结合古代及现代对炎症和癌症的认识,提炼出“热极成毒”可能为肺“炎-癌转化”进程的核心病机,但火热当从标本虚实分论,从标从实,邪踞而郁热生,毒乃成,从本从虚,正虚而阴火生,积则成,终至由炎症转化成为肺癌。进而提出辨治肺“炎-癌转化”思路,一者宜审因论治,清热解毒以攻外邪;二者应治病求本,补土生金以扶内虚;三者宜体功同调,宣通适宜以顺肺性。以期为中医药干预肺“炎-癌转化”进程提供理论依据,为中医防治肺癌提供有益参考。“Inflammation-cancer transformation” is a general term for the transformation of inflammation-related diseases to the occurrence and development of cancer.Traditional Chinese medicine(TCM)recognizes that inflammation is caused byfire-evil,heat-evil,and toxin-evil.Blocking the process of “inflammation-cancer transformation” can delay the occurrence and development of lung cancer.Based on the theory of “heat polarized toxicity” and the ancient and modern understanding of inflammation and cancer,this study concludes that “heat polarized toxicity” may be the core pathogenicfactor of lung “inflammation-cancer transformation.” However,fire-evil and heat-evil should be separated from the manifestation and root cause of the disease.From the point of view of symptoms and reality,the stagnation of evil leads to fire and heat.From the perspective of root cause and deficiency,the deficiency leads to yin fire-evil,which causes accumulation.Subsequently,the inflammation becomes cancer.Furthermore,the differential treatment of lung “inflammation-cancer transformation” has been put forward.On the one hand,we should attach importance to the cause,clearing away heat and detoxification in order to attack external evil.On the other hand,we should cure the disease by seeking root,tonifying soil,and promoting gold to support positive deficiency.In addition,our treatments should be in tune with physical function,and Xuan Tong should be suitable for compliance with the lung.We provide a theoretical basis for TCM intervention in the process of lung “inflammation-cancer transformation” and a useful reference for the prevention and treatment of lung cancer based on TCM.

关 键 词：肺癌 炎症 热极成毒 炎-癌转化 

分 类 号：R273[医药卫生—中西医结合]