骨科内植物表面抗菌改性的研究进展  

Research progress of antibacterial modification of orthopaedic implants surface

作　　者：张超群 吴一芃 徐永清 ZHANG Chaoqun;WU Yipeng;XU Yongqing(Graduate School of Kunming Medical University,Kunming Yunnan,650000,P.R.China;Institute of All-Army Trauma Orthopaedics,No.920 Hospital of PL A Joint Service Support Force,Kunming Yunnan,650032,P.R.China)

机构地区：[1]昆明医科大学研究生院,昆明650000 [2]解放军联勤保障部队第九二○医院全军创伤骨科研究所,昆明650032

出　　处：《中国修复重建外科杂志》2022年第4期511-516,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(82072392)。

摘　　要：目的 总结近年骨科内植物表面抗菌改性的相关研究进展。方法 广泛查阅近年国内外相关文献,从骨科内植物的感染特点和表面抗感染修饰两方面探讨骨科内植物表面抗菌改性的研究进展。结果 骨科内植物感染主要与细菌黏附、宿主免疫能力下降和表面生物膜形成等方面有关。目前骨科内植物表面抗菌改性方式主要有抗细菌黏附涂层、抗生素涂层、无机抗菌剂涂层、复合型抗菌涂层、一氧化氮涂层、免疫调节治疗、基于3D打印的表面涂层、高分子类抗菌涂层、“智能”涂层。结论 目前的骨科内植物表面抗菌改性方式不仅能够抑制细菌黏附,还可以解决宿主免疫能力下降和生物膜形成的问题。但其作用机制和修饰方式尚存争议,有待进一步研究。Objective To summarize the related research progress of antibacterial modification of orthopaedic implants surface in recent years. Methods The domestic and foreign related literature in recent years was extensively consulted, the research progress on antibacterial modification of orthopaedic implants surface was discussed from two aspects of characteristics of infection in orthopedic implants and surface anti-infection modification. Results The orthopaedic implants infections are mainly related to aspects of bacterial adhesion, decreased host immunity, and surface biofilm formation. At present, the main antimicrobial coating methods of orthopaedic implants are antibacterial adhesion coating, antibiotic coating, inorganic antimicrobial coating, composite antimicrobial coating, nitric oxide coating,immunomodulation, three-dimensional printing, polymer antimicrobial coating, and “smart” coating. Conclusion The above-mentioned antibacterial coating methods of orthopedic implants can not only inhibit bacterial adhesion, but also solve the problems of low immunity and biofilm formation. However, its mechanism of action and modification are still controversial and require further research.

关 键 词：骨科内植物 抗感染治疗 表面抗菌改性 

分 类 号：R68[医药卫生—骨科学]