木犀草素纳米乳对DPPH·自由基的清除活性研究  

Investigation on Scavenging Effect of Luteolin Nanoemulsion on DPPH· Free Radical

作　　者：胡泽香 佟雷[1] 耿艳萌[2] 杨琦 谢舒 侯甲福[1] HU Zexiang;TONG Lei;GENG Yanmeng;YANG Qi;XIE Shu;HOU Jiafu(College of Pharmacy,Mudanjiang Medical University,Mudanjiang 157011,China;College of Public Health,Mudanjiang Medical University,Mudanjiang 157011,China)

机构地区：[1]牡丹江医学院药学院,黑龙江牡丹江157011 [2]牡丹江医学院公共卫生学院,黑龙江牡丹江157011

出　　处：《安徽科技学院学报》2021年第6期73-76,共4页Journal of Anhui Science and Technology University

基　　金：牡丹江市应用技术研究与开发计划项目(HT2020NS083)。

摘　　要：目的:通过DPPH·自由基实验考察木犀草素纳米乳的抗氧化能力。方法:以Vc作为阳性对照,通过木犀草素纳米乳对DPPH·自由基的清除能力来评价其抗氧化活性。结果:木犀草素纳米乳和Vc均对DPPH·自由基具有一定的清除作用,且清除率与药物浓度在0.002~0.014 mg/mL范围内呈正相关。木犀草素纳米乳的抗氧化活性很强,略低于Vc。结论:木犀草素纳米乳具有较强的抗氧化活性。Objective: To investigate the antioxidant capacity of luteolin nanoemulsion by DPPH· free radical. Methods: The antioxidant activity of luteolin nanoemulsion was evaluated by the scavenging ability of DPPH· free radical with Vc as positive control. Results: Both luteolin nanoemulsion and Vc showed scavenging effect on DPPH· free radical and the scavenging rate was positively correlated with the drug concentration in the range of 0.002-0.014 mg/mL. The antioxidant activity of luteolin nanoemulsion was strong, but slightly lower than that of Vc. Conclusion: Luteolin nanoemulsion has strong antioxidant activity.

关 键 词：木犀草素纳米乳 抗氧化 DPPH 

分 类 号：R944[医药卫生—药剂学]