2型糖尿病患者发生高尿酸血症的影响因素研究  

Study on influencing factors of hyperuricemia in patients with type 2 diabetes mellitus

作　　者：牟琳 李超[2] 赵文颖 董欢[1] 王媛 李欣 张宝玉[1] 杨龙艳 MU Lin;LI Chao;ZHAO Wenying;DONG Huan;WANG Yuan;LI Xin;ZHANG Baoyu;YANG Longyan(Center for Endocrine Metabolism and Immune Diseases,Beijing Luhe Hospital,Capital Medical University,Beijing 101149,China;Department of Cardiology,the First Medical Center,Chinese PLA General Hospital,Beijing 100039,China;Beijing Key Laboratory of Diabetes Research and Care,Beijing Luhe Hospital,Capital Medical University,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京潞河医院内分泌代谢与免疫性疾病中心,北京101149 [2]解放军总医院第一医学中心心血管内科,北京100039 [3]首都医科大学附属北京潞河医院糖尿病防治研究北京市重点实验室,北京101149

出　　处：《中国医药导报》2022年第9期67-69,78,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81800768)。

摘　　要：目的探索2型糖尿病人群发生高尿酸血症的影响因素。方法回顾性纳入2017年10月至2021年2月于首都医科大学附属北京潞河医院内分泌代谢与免疫性疾病中心就诊的3427例2型糖尿病患者,收集其人口学、临床和生活习惯资料。根据是否并发高尿酸血症将其分为高尿酸血症组(399例)和对照组(3028例),通过单因素和多因素分析评价2型糖尿病患者发生高尿酸血症的影响因素。结果高尿酸血症组收缩压、舒张压、身高、体重、体重指数、腰围、高血压占比、高脂血症占比、冠心病占比、外周血管病占比、摄入充足豆制品占比、年收入>10万元占比均高于对照组,差异有统计学意义(P<0.05)。多因素分析结果显示,高血压、高脂血症、年收入>10万元和充足的豆制品摄入均为2型糖尿病患者发生高尿酸血症的独立危险因素(OR>1,P<0.05)。结论高血压、高脂血症、年收入>10万元和充足的豆制品摄入均为2型糖尿病患者发生高尿酸血症的影响因素。Objective To explore the influencing factors of hyperuricemia in type 2 diabetes mellitus.Methods A total of 3427 patients with type 2 diabetes mellitus admitted to the Center for Endocrine Metabolism and Immune Diseases,Beijing Luhe Hospital,Capital Medical University from October 2017 to February 2021 were retrospectively enrolled,and their data of demographic,clinical,and lifestyle were collected.They were divided into hyperuricemia group(399 cases)and control group(3028 cases)according to whether they were complicated with hyperuricemia.Univariate and multivariate analyses were conducted to evaluate the influencing factors of hyperuricemia in patients with type 2 diabetes mellitus.Results Systolic blood pressure,diastolic blood pressure,height,weight,body mass index,waist circumference,proportion of hypertension,proportion of hyperlipidemia,proportion of coronary heart disease,proportion of peripheral vascular disease,proportion of intake of adequate soy products,and proportion of annual income>100000 yuan in hyperuricemia group were all higher than those in control group,the differences were statistically significant(P<0.05).Multivariate analysis showed that hypertension,hyperlipidemia,annual income>100000 yuan,and adequate intake of soy products were independent risk factors for hyperuricemia in patients with type 2 diabetes mellitus(OR>1,P<0.05).Conclusion Hypertension,hyperlipidemia,annual income>100000 yuan,and adequate intake of soy products are the influencing factors of hyperuricemia in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病 高尿酸血症 高血压 高脂血症 收入 影响因素 

分 类 号：R587.1[医药卫生—内分泌]