补体C1q/肿瘤坏死因子相关蛋白5与妊娠糖尿病的关系  

Relationship between complement-C1q/tumor necrosis factor-related protein 5 and gestational diabetes mellitus

作　　者：辛雅萍[1] 祝艺菡 张琦 张珂[2] 王安英[2] XIN Yaping;ZHU Yihan;ZHANG Qi;ZHANG Ke;WANG Anying(Department of Endocrinology,the Second Affiliated Hospital of Zhengzhou University,Henan Province,Zhengzhou 450000,China;Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Zhengzhou University,Henan Province,Zhengzhou 450000,China)

机构地区：[1]郑州大学第二附属医院内分泌科,河南郑州450000 [2]郑州大学第二附属医院妇产科,河南郑州450000

出　　处：《中国医药导报》2022年第9期75-78,共4页China Medical Herald

基　　金：河南省医学科技攻关计划项目(201702094)。

摘　　要：目的探讨补体C1q/肿瘤坏死因子相关蛋白5(CTRP5)与妊娠糖尿病(GDM)的关系。方法选取2020年6月至2021年6月郑州大学第二附属医院孕检的孕妇172名,按是否患有GDM将其分为对照组(80名)和GDM组(92例)。比较两组年龄、孕龄、孕前体重指数(BMI)、产前BMI、血压、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、葡萄糖负荷2 h血糖、空腹胰岛素(FINS)、糖化血红蛋白(HbA_(1c))、稳态模型胰岛素抵抗(HOMA-IR)指数、CTRP5和脂肪甘油三酯脂肪酶(ATGL)。分析CTRP5与各指标的相关性,并通过logistic回归模型分析CTRP5与GDM的关系。结果GDM组孕前BMI、产前BMI、TC、TG、FBG、葡萄糖负荷2 h血糖、HbA_(1c)、FINS、HOMA-IR指数均高于对照组,ATGL、CTRP5均低于对照组,差异有统计学意义(P<0.05)。CTRP5与孕前BMI、产前BMI、TC、TG、FBG、HbA_(1c)、葡萄糖负荷2 h血糖、FINS、HOMA-IR指数呈负相关(r<0,P<0.05),与ATGL呈正相关(r>0,P<0.05)。logistic回归模型分析结果显示,校正孕前BMI、产前BMI、TC、TG、FBG、HbA_(1c)、葡萄糖负荷2 h血糖、FINS、HOMA-IR指数后,CTRP5仍为GDM发生的独立影响因素(P<0.05)。结论CTRP5是GDM的影响因素,可能与胰岛素抵抗和糖脂代谢有关。Objective To study relationship between complement-C1q/tumor necrosis factor-related protein 5(CTRP5)and gestational diabetes mellitus(GDM).Methods A total of 172 gravidas enrolled in the Second Affiliated Hospital of Zhengzhou University from June 2020 to June 2021 were divided into control group(80 gravidas)and GDM group(92 cases)according to whether they had GDM or not.Age,gestational age,pre-pregnancy body mass index(BMI),prenatal BMI,blood pressure,total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),fasting blood glucose(FBG),glucose load 2 h blood glucose,fasting insulin(FINS),glycated hemoglobin(HbA_(1c)),homeostasis model assessment-insulin resistance(HOMA-IR)index,CTRP5,and adipose triglyceride lipase(ATGL)were compared between the two groups.The correlation between CTRP5 and all indicators was analyzed,and the relationship between CTRP5 and GDM was analyzed by logistic regression model.Results Pre-pregnancy BMI,prenatal BMI,TC,TG,FBG,glucose load 2 h blood glucose,HbA_(1c),FINS,and HOMA-IR indexes in GDM group were all higher than those in control group,while ATGL and CTRP5 were all lower than those in control group,the differences were statistically significant(P<0.05).CTRP5 was negatively correlated with pre-pregnancy BMI,prenatal BMI,TC,TG,FBG,HbA_(1c),glucose load 2 h blood glucose,FINS,HOMA-IR index(r<0,P<0.05),and positively correlated with ATGL(r>0,P<0.05).Logistic regression model analysis showed that CTRP5 was still an independent influencing factor for the occurrence of GDM after adjusting pre-pregnancy BMI,prenatal BMI,TC,TG,FBG,HbA_(1c),glucose load 2 h blood glucose,FINS,and HOMA-IR index(P<0.05).Conclusion CTRP5 is an influential factor of GDM,which may be related to insulin resistance and glycolipid metabolism.

关 键 词：妊娠糖尿病 补体C1q/肿瘤坏死因子相关蛋白5 胰岛素抵抗 糖脂代谢 

分 类 号：R714.2[医药卫生—妇产科学]