慢性阻塞性肺疾病急性加重期痰热壅肺证的用药规律探讨  

Discussion on medication rules of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome

作　　者：杜娟[1] 里自然 叶焰 DU Juan;LI Ziran;YE Yan(Department of Pulmonary Diseases,Guangzhou Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine,Guangdong Province,Guangzhou 510130,China;Department of Pulmonary Diseases,the Affiliated TCM Hospital of Guangzhou Medical University,Guangdong Province,Guangzhou 510130,China)

机构地区：[1]广州中医药大学附属广州中医医院肺病科,广东广州510130 [2]广州医科大学附属中医医院肺病科,广东广州510130

出　　处：《中国医药导报》2022年第8期143-146,168,共5页China Medical Herald

基　　金：广东省中医药局科研项目(20211295);广东省广州市卫生健康科技项目(20202A010004)。

摘　　要：目的探讨慢性阻塞性肺疾病急性加重期痰热壅肺证的中医用药规律。方法以“慢性阻塞性肺疾病急性加重期”或“AECOPD”和“痰热”为主题词,搜索中国知网、万方、维普数据库2010年1月至2021年6月收录的文献并建立数据库,使用Excel 2019、SPSS Modeler 18.0、SPSS Statistics 26.0软件,分析处方的用药频次、功效、性味归经和关联药对、聚类组方等。结果纳入126篇文献,含128首处方,共178种中药,前5位高频药物是黄芩、苦杏仁、法半夏、甘草、桑白皮,以清热化痰、止咳平喘药为主。药味以苦、甘、辛为主,药性以寒、温、平为主,归经主要在肺、胃、肝、脾等。关联度最高的药对为紫苏子、桑白皮,聚类分析得到药物分类5类。结论清热化痰、止咳平喘是慢性阻塞性肺疾病急性加重期痰热壅肺证的核心治则,理气、化湿、活血、泻下药随证搭配。Objective To explore the medication rules of Chinese medicine of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome.Methods The subject words were“acute exacerbation of chronic obstructive pulmonary disease”or“AECOPD”and“phlegm heat”.The literatures included in CNKI,Wanfang and VIP database from January 2010 to June 2021 were searched and prescription database was established.Excel 2019,SPSS Modeler 18.0,and SPSS Statistics 26.0 softwares were used to analyze frequency,efficacy,meridian tropism,related drug pairs,and clustering prescription.Results A total of 126 articles and 128 prescriptions were counted,including 178 herbs.The top five high frequency drugs were Scutellariae Radix,Armeniacae Semen Amarum,Pinelliae Rhizoma Praeparatum,Glycyrrhizae Radix et Rhizoma,Mori Cortex.It was mainly used for clearing heat and resolving phlegm,relieving cough and relieving asthma.The taste of medicine was mainly bitter,sweet and pungent,and its properties were mainly cold,warm and flat,and its meridians were mainly in lung,stomach,liver and spleen,and so on.The drug pairs with the highest correlation were Perillae Fructus and Mori Cortex.Five kinds of drugs were classified by cluster analysis.Conclusion Clearing heat and resolving phlegm,relieving cough and relieving asthma are the core treatment principles of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome.Drugs for regulating qi,removing dampness,promoting blood circulation and diarrhea are matched with the syndrome.

关 键 词：慢性阻塞性肺疾病 急性加重期 痰热壅肺证 数据挖掘 用药规律 

分 类 号：R256.1[医药卫生—中医内科学]