滋养细胞铁死亡在胎盘相关疾病中的研究进展  

Research Progress of Trophoblast Ferroptosis in Placenta Related Diseases

作　　者：董辉 陈叙(审校)[1] DONG Hui;CHEN Xu(Department of Obstetrics,Tianjin Central Hospital of Gynecology and Obstetrics/Nankai University Affiliated Maternity Hospital,Tianjin 300100,China)

机构地区：[1]天津市中心妇产科医院/南开大学附属妇产医院产科,300100

出　　处：《国际妇产科学杂志》2022年第2期129-132,146,共5页Journal of International Obstetrics and Gynecology

基　　金：天津市卫生健康科技项目(KJ20127)。

摘　　要：铁死亡是一种铁依赖性的,区别于细胞凋亡、焦亡、坏死和自噬的新型细胞程序性死亡方式,是细胞内脂质活性氧代谢失衡、细胞抗氧化能力降低和膜脂质过氧化物堆积引起细胞氧化性死亡的过程。母胎界面形成期间出现的滋养细胞缺血-再灌注及缺氧-复氧过程可产生大量的活性氧,并且滋养细胞富含多不饱和脂肪酸,铁离子负荷大,因此滋养细胞是铁死亡的易感细胞。滋养细胞的铁死亡可影响其侵袭、增殖能力,造成子宫螺旋动脉重塑不良及胎盘浸润不足,引起胎盘功能障碍,并参与到子痫前期、早产和妊娠期糖尿病等胎盘相关疾病的发生、发展过程中。滋养细胞铁死亡调控机制复杂,有待进一步研究,并有望为深入研究、治疗胎盘相关疾病提供新策略。Ferroptosis is a new type of programmed cell death which is iron-dependent and different from apoptosis,pyroptosis,necrosis and autophagy.It is a process of oxidative death caused by imbalance of intracellular lipid reactive oxygen species metabolism,reduction of cell antioxidant capacity and accumulation of membrane lipid peroxides.The process of ischemia-reperfusion and anoxia reoxygenation of trophoblast during the formation of maternal fetal interface can produce a lot of reactive oxygen species,and trophoblast is rich in polyunsaturated fatty acids and has a high load of iron ions,so it is a susceptible cell of iron death.Ferroptosis of trophoblast may affect its invasion and proliferation ability,resulting in insufficient placenta infiltration and poor remodeling of uterine spiral arteries,causing placental dysfunction,and is involved in the development of placental related diseases such as pre-eclampsia,preterm delivery,gestational diabetes mellitus and so on.The regulatory mechanism of trophoblast iron death is complex,which needs further study,and is expected to provide new strategies for the study and treatment of placental related diseases.

关 键 词：滋养层 铁死亡 高血压 妊娠性 流产 自然 糖尿病 妊娠 

分 类 号：R714.56[医药卫生—妇产科学]