恩格列净联合二甲双胍治疗2型糖尿病的效果  

Effiect of Enpagliflozin combined with Metformin in the treatment of type 2 diabetes mellitus

作　　者：牛尚梅[1] 宋潇萌 张晓杰 杨英焘 郭会军 韩世超[1] NIU Shangmei;SONG Xiaomeng;ZHANG Xiaojie;YANG Yingtao;GUO Huijun;HAN Shichao(The Second Department of Endocrinology,Handan First Hospital,Hebei Province,Handan 056002,China;the Fourth Department of Cardiology,Handan First Hospital,Hebei Province,Handan 056002,China)

机构地区：[1]河北省邯郸市第一医院内分泌二科,河北邯郸056002 [2]河北省邯郸市第一医院心内四科,河北邯郸056002

出　　处：《中国医药导报》2022年第6期76-80,共5页China Medical Herald

基　　金：河北省医学科学研究课题计划项目(20211123)。

摘　　要：目的探讨恩格列净联合二甲双胍治疗2型糖尿病(T2DM)的效果。方法选取2018年11月至2020年2月河北省邯郸市第一医院内分泌科就诊的200例T2DM患者,按随机数字表法分为对照组和观察组,每组各100例。其中,对照组给予二甲双胍,观察组给予恩格列净联合二甲双胍,疗程均为12个月。治疗后比较两组糖代谢指标、心脏超声检测指标、体重、平均动脉压、钠离子、血清尿酸水平,并记录治疗期间不良反应的发生情况。结果治疗后两组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于治疗前,且观察组低于对照组(P<0.05)。治疗后两组E峰、LVEF、LV质量指数均降低,且观察组均优于对照组(P<0.05)。治疗后两组体重、平均动脉压、钠离子、血清尿酸水平均低于治疗前,且观察组低于对照组(P<0.05)。治疗后两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论恩格列净联合二甲双胍治疗T2DM能提高患者血糖控制度,并通过调节患者血糖,降低患者体重、血清尿酸,维持血压及钠离子水平,保护T2DM患者心血管系统。Objective To explore the effect of Empagliflozin combined with Metformin on patients with type 2 diabetes mellitus(T2DM).Methods A total of 200 T2DM patients admitted to the Department of Endocrinology of the Handan First Hospital,Hebei Province from November 2018 to February 2020,and they were divided into control group and observation group according to the random number table method,with 100 cases in each group.Among them,the control group was given Metformin,and the observation group was given Enggliazin combined with Metformin,and the treatment course was 12 months.After treatment,glucose metabolism indexes,cardiac ultrasound detection indexes,body weight,mean arterial pressure,sodium ion,and serum uric acid levels were compared between the two groups,and the occurrence of adverse reactions during treatment was recorded.Results After treatment,the levels of fasting blood glucose,2 hours postprandial blood glucose,and glycosylated hemoglobin in two groups were lower than before,and the observation group was lower than the control group(P<0.05).After treatment,the E peak,LVEF,and LV mass index in the two groups were decreased,but the observation group was better than those of the control group(P<0.05).After treatment,body weight,mean arterial pressure,sodium ion,and serum uric acid levels in two groups were lower than before,and observation group was lower than those of control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion Enpagliflozin combined with Metformin in the treatment of T2DM can improve the patient’s blood glucose control,and by regulating the patient’s blood sugar,reducing the patient’s body weight,serum uric acid,maintaining blood pressure,and sodiumion levels,and protecting the cardiovascular system of T2DM patients.

关 键 词：恩格列净 2型糖尿病 心血管 作用机制 

分 类 号：R58[医药卫生—内分泌]